Association Between Prematurity and the Evolution of Psychotic Disorders in 22q11.2 Deletion Syndrome

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2016 Aug 13

PMID 27517838

Citations 5

Authors

Yael Midbari Kufert

Ariela Nachmani

Einat Nativ

Abraham Weizman

Doron Gothelf

Affiliations

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Abstract

In this study, we report the developmental, physical and psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS) in a large Israeli cohort, and search for a possible association between preterm birth and the risk for psychotic disorders. The study population consisted of 128 individuals with 22q11.2DS (77 male, 51 female), aged 1-55 years (mean ± SD 12.9 ± 11.0). All subjects underwent a comprehensive medical evaluation. All subjects older than 5 years (n = 104) were also evaluated psychiatrically. Overall, we found rates of physical manifestations similar to those previously reported in the literature. Psychiatric disorders were very common among our study population, with psychotic disorders occurring in 16.3 % of the psychiatrically evaluated population. We found an association between the presence of psychotic disorders and preterm birth. Our results replicate and extend the findings of a previous work and suggest that the evolution of psychosis in 22q11.2DS is a neurodevelopmental process with early obstetric and medical precursors.

Citing Articles

The Co-Occurrence of 22q11.2 Deletion Syndrome and Epithelial Basement Membrane Dystrophy: A Case Report and Review of the Literature.

Armentano M, Alisi L, Giovannetti F, Iannucci V, Lucchino L, Bruscolini A Life (Basel). 2024; 14(8).

PMID: 39202748 PMC: 11355887. DOI: 10.3390/life14081006.

Ocular findings in 22q11.2 deletion syndrome: A systematic literature review and results of a Dutch multicenter study.

von Scheibler E, van der Valk Bouman E, Nuijts M, Bauer N, Berendschot T, Vermeltfoort P Am J Med Genet A. 2021; 188(2):569-578.

PMID: 34773366 PMC: 9298823. DOI: 10.1002/ajmg.a.62556.

Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS.

Bagautdinova J, Padula M, Zoller D, Sandini C, Schneider M, Schaer M Transl Psychiatry. 2020; 10(1):408.

PMID: 33235187 PMC: 7686319. DOI: 10.1038/s41398-020-01090-z.

A Mini Review on the Contribution of the Anterior Cingulate Cortex in the Risk of Psychosis in 22q11.2 Deletion Syndrome.

Padula M, Scariati E, Schaer M, Eliez S Front Psychiatry. 2018; 9:372.

PMID: 30174623 PMC: 6107828. DOI: 10.3389/fpsyt.2018.00372.

Neuropsychiatric aspects of 22q11.2 deletion syndrome: considerations in the prenatal setting.

Bassett A, Costain G, Marshall C Prenat Diagn. 2016; 37(1):61-69.

PMID: 27718271 PMC: 5243851. DOI: 10.1002/pd.4935.

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