Reporting of Financial and Non-financial Conflicts of Interest by Authors of Systematic Reviews: a Methodological Survey

Overview

Journal BMJ Open

Specialty General Medicine

Date 2016 Aug 13

PMID 27515760

Citations 19

Authors

Maram B Hakoum

Sirine Anouti

Mounir Al-Gibbawi

Elias A Abou-Jaoude

Divina Justina Hasbani

Luciane Cruz Lopes

Arnav Agarwal

Gordon Guyatt

Elie A Akl

Affiliations

Soon will be listed here.

Abstract

Background: Conflicts of interest may bias the findings of systematic reviews. The objective of this methodological survey was to assess the frequency and different types of conflicts of interest that authors of Cochrane and non-Cochrane systematic reviews report.

Methods: We searched for systematic reviews using the Cochrane Database of Systematic Reviews and Ovid MEDLINE (limited to the 119 Core Clinical Journals and the year 2015). We defined a conflict of interest disclosure as the reporting of whether a conflict of interest exists or not, and used a framework to classify conflicts of interest into individual (financial, professional and intellectual) and institutional (financial and advocatory) conflicts of interest. We conducted descriptive and regression analyses.

Results: Of the 200 systematic reviews, 194 (97%) reported authors' conflicts of interest disclosures, typically in the main document, and in a few cases either online (2%) or on request (5%). Of the 194 Cochrane and non-Cochrane reviews, 49% and 33%, respectively, had at least one author reporting any type of conflict of interest (p=0.023). Institutional conflicts of interest were less frequently reported than individual conflicts of interest, and Cochrane reviews were more likely to report individual intellectual conflicts of interest compared with non-Cochrane reviews (19% and 5%, respectively, p=0.004). Regression analyses showed a positive association between reporting of conflicts of interest (at least one type of conflict of interest, individual financial conflict of interest, institutional financial conflict of interest) and journal impact factor and between reporting individual financial conflicts of interest and pharmacological versus non-pharmacological intervention.

Conclusions: Although close to half of the published systematic reviews report that authors (typically many) have conflicts of interest, more than half report that they do not. Authors reported individual conflicts of interest more frequently than institutional and non-financial conflicts of interest.

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References

Schunemann H, Al-Ansary L, Forland F, Kersten S, Komulainen J, Kopp I . Guidelines International Network: Principles for Disclosure of Interests and Management of Conflicts in Guidelines. Ann Intern Med. 2015; 163(7):548-53. DOI: 10.7326/M14-1885. View

Borenstein M, Hedges L, Higgins J, Rothstein H . A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2015; 1(2):97-111. DOI: 10.1002/jrsm.12. View

Harris P, Taylor R, Thielke R, Payne J, Gonzalez N, Conde J . Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2008; 42(2):377-81. PMC: 2700030. DOI: 10.1016/j.jbi.2008.08.010. View

Iqbal S, Wallach J, Khoury M, Schully S, Ioannidis J . Reproducible Research Practices and Transparency across the Biomedical Literature. PLoS Biol. 2016; 14(1):e1002333. PMC: 4699702. DOI: 10.1371/journal.pbio.1002333. View

Dunn A, Arachi D, Hudgins J, Tsafnat G, Coiera E, Bourgeois F . Financial conflicts of interest and conclusions about neuraminidase inhibitors for influenza: an analysis of systematic reviews. Ann Intern Med. 2014; 161(7):513-8. DOI: 10.7326/M14-0933. View

Ancker J, Flanagin A . A comparison of conflict of interest policies at peer-reviewed journals in different scientific disciplines. Sci Eng Ethics. 2007; 13(2):147-57. DOI: 10.1007/s11948-007-9011-z. View

Shawwa K, Kallas R, Koujanian S, Agarwal A, Neumann I, Alexander P . Requirements of Clinical Journals for Authors' Disclosure of Financial and Non-Financial Conflicts of Interest: A Cross Sectional Study. PLoS One. 2016; 11(3):e0152301. PMC: 4816392. DOI: 10.1371/journal.pone.0152301. View

Guyatt G, Akl E, Hirsh J, Kearon C, Crowther M, Gutterman D . The vexing problem of guidelines and conflict of interest: a potential solution. Ann Intern Med. 2010; 152(11):738-41. DOI: 10.7326/0003-4819-152-11-201006010-00254. View

Bhattacharyya N, Lin H . Prevalence and reliability of self-reported authorship disclosures in Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg. 2009; 141(3):311-5. DOI: 10.1016/j.otohns.2009.06.010. View

10.

Schunemann H, Osborne M, Moss J, Manthous C, Wagner G, Sicilian L . An official American Thoracic Society Policy statement: managing conflict of interest in professional societies. Am J Respir Crit Care Med. 2009; 180(6):564-80. DOI: 10.1164/rccm.200901-0126ST. View

11.

Okike K, Kocher M, Wei E, Mehlman C, Bhandari M . Accuracy of conflict-of-interest disclosures reported by physicians. N Engl J Med. 2009; 361(15):1466-74. DOI: 10.1056/NEJMsa0807160. View

12.

Bes-Rastrollo M, Schulze M, Ruiz-Canela M, Martinez-Gonzalez M . Financial conflicts of interest and reporting bias regarding the association between sugar-sweetened beverages and weight gain: a systematic review of systematic reviews. PLoS Med. 2014; 10(12):e1001578. PMC: 3876974. DOI: 10.1371/journal.pmed.1001578. View

13.

Glaser B, Bero L . Attitudes of academic and clinical researchers toward financial ties in research: a systematic review. Sci Eng Ethics. 2005; 11(4):553-73. DOI: 10.1007/s11948-005-0026-z. View

14.

Ebrahim S, Bance S, Athale A, Malachowski C, Ioannidis J . Meta-analyses with industry involvement are massively published and report no caveats for antidepressants. J Clin Epidemiol. 2015; 70:155-63. DOI: 10.1016/j.jclinepi.2015.08.021. View

15.

Viswanathan M, Carey T, Belinson S, Berliner E, Chang S, Graham E . A proposed approach may help systematic reviews retain needed expertise while minimizing bias from nonfinancial conflicts of interest. J Clin Epidemiol. 2014; 67(11):1229-38. DOI: 10.1016/j.jclinepi.2014.02.023. View

16.

Oxman A, Guyatt G . The science of reviewing research. Ann N Y Acad Sci. 1993; 703:125-33; discussion 133-4. DOI: 10.1111/j.1749-6632.1993.tb26342.x. View

17.

Blum J, Freeman K, Dart R, Cooper R . Requirements and definitions in conflict of interest policies of medical journals. JAMA. 2009; 302(20):2230-4. DOI: 10.1001/jama.2009.1669. View

18.

Beyari M, Strain D, Li C, Lamfon H . Conflict of interest reporting in dentistry meta-analyses: A systematic review. J Clin Exp Dent. 2014; 6(3):e280-5. PMC: 4134859. DOI: 10.4317/jced.51225. View

19.

Meslin E, Rager J, Schwartz P, Quaid K, Gaffney M, Duke J . Benchmarks for ethically credible partnerships between industry and academic health centers: beyond disclosure of financial conflicts of interest. Clin Transl Med. 2015; 4(1):36. PMC: 4678144. DOI: 10.1186/s40169-015-0077-y. View

20.

Maharaj S . A new method for scoring financial conflicts of interest. Int J Occup Environ Health. 2015; 21(1):49-52. PMC: 4273519. DOI: 10.1179/2049396714Y.0000000097. View