Alpha 2.0
Login Register
» Articles » PMID: 27512511

Association of Human Leukocyte Antigen Class II Alleles with Severe Middle East Respiratory Syndrome-coronavirus Infection

Overview
Journal Ann Thorac Med
Specialty Pulmonary Medicine
Date 2016 Aug 12
PMID 27512511
Citations 50
Authors
Ali H Hajeer
Hanan Balkhy
Sameera Johani
Mohammed Z Yousef
Yaseen Arabi
Affiliations
Soon will be listed here.
Abstract

Background: Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.

Aim: We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.

Methods: A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.

Results: Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.

Conclusions: Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.

Citing Articles

Advanced biomaterials for regenerative medicine and their possible therapeutic significance in treating COVID-19: a critical overview.

Sarangi A, Salem M, Younus M, El-Haroun H, Mahal A, Tripathy L Int J Surg. 2024; 110(12):7508-7527.

PMID: 39411890 PMC: 11634172. DOI: 10.1097/JS9.0000000000002110.

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population.

Vica M, Dobreanu M, Curocichin G, Matei H, Balici S, Vuscan M Int J Mol Sci. 2024; 25(2).

PMID: 38279325 PMC: 10816224. DOI: 10.3390/ijms25021326.

HLA-B27 did not protect against COVID-19 in patients with axial spondyloarthritis - data from the ReumaCov-Brasil Registry.

Mota G, Marques C, Ribeiro S, Albuquerque C, Castro G, Fernandino D Adv Rheumatol. 2023; 63(1):56.

PMID: 38031143 DOI: 10.1186/s42358-023-00340-0.

Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes.

Shapiro J, Roberts C, Arcovio K, Reade L, Klein S, Dhakal S Curr Top Microbiol Immunol. 2023; 441:75-110.

PMID: 37695426 DOI: 10.1007/978-3-031-35139-6_4.

COVID-19 annual update: a narrative review.

Biancolella M, Colona V, Luzzatto L, Watt J, Mattiuz G, Conticello S Hum Genomics. 2023; 17(1):68.

PMID: 37488607 PMC: 10367267. DOI: 10.1186/s40246-023-00515-2.

References
1.
Al-Tawfiq J, Memish Z . Middle East respiratory syndrome coronavirus: epidemiology and disease control measures. Infect Drug Resist. 2014; 7:281-7. PMC: 4226520. DOI: 10.2147/IDR.S51283. View
2.
Zaki A, van Boheemen S, Bestebroer T, Osterhaus A, Fouchier R . Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012; 367(19):1814-20. DOI: 10.1056/NEJMoa1211721. View
3.
Ng M, Cheng S, Lau K, Leung G, Khoo U, Zee B . Immunogenetics in SARS: a case-control study. Hong Kong Med J. 2010; 16(5 Suppl 4):29-33. View
4.
Lin M, Tseng H, Trejaut J, Lee H, Loo J, Chu C . Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med Genet. 2003; 4:9. PMC: 212558. DOI: 10.1186/1471-2350-4-9. View
5.
Hajeer A, Al Balwi M, Uyar F, Alhaidan Y, Alabdulrahman A, Al Abdulkareem I . HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique. Tissue Antigens. 2014; 82(4):252-8. DOI: 10.1111/tan.12200. View