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Empagliflozin's Fuel Hypothesis: Not So Soon

Overview
Journal Cell Metab
Publisher Cell Press
Date 2016 Aug 11
PMID 27508868
Citations 57
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Abstract

The EMPA-REG OUTCOME trial (Zinman et al., 2015) established cardioprotective effects of empagliflozin in high-risk diabetic patients, but the underlying mechanisms remain elusive. A recent hypothesis proposed that increased ketone oxidation contributed to the effect, but several caveats indicate that the role of myocardial ketone oxidation is far from clear.

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