Glycoengineering of Plants Yields Glycoproteins with Polysialylation and Other Defined N-glycoforms

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2016 Aug 11

PMID 27506788

Citations 22

Authors

Qiang Chen

Affiliations

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Citing Articles

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References

Zeitlin L, Pettitt J, Scully C, Bohorova N, Kim D, Pauly M . Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant. Proc Natl Acad Sci U S A. 2011; 108(51):20690-4. PMC: 3251097. DOI: 10.1073/pnas.1108360108. View

Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti J . Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature. 2014; 514(7520):47-53. PMC: 4214273. DOI: 10.1038/nature13777. View

He J, Lai H, Engle M, Gorlatov S, Gruber C, Steinkellner H . Generation and analysis of novel plant-derived antibody-based therapeutic molecules against West Nile virus. PLoS One. 2014; 9(3):e93541. PMC: 3968140. DOI: 10.1371/journal.pone.0093541. View

Loos A, Steinkellner H . Plant glyco-biotechnology on the way to synthetic biology. Front Plant Sci. 2014; 5:523. PMC: 4189330. DOI: 10.3389/fpls.2014.00523. View

Jain S, Hreczuk-Hirst D, McCormack B, Mital M, Epenetos A, Laing P . Polysialylated insulin: synthesis, characterization and biological activity in vivo. Biochim Biophys Acta. 2003; 1622(1):42-9. DOI: 10.1016/s0304-4165(03)00116-8. View

Lai H, He J, Hurtado J, Stahnke J, Fuchs A, Mehlhop E . Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants. Plant Biotechnol J. 2014; 12(8):1098-107. PMC: 4175135. DOI: 10.1111/pbi.12217. View

Varki A . Evolutionary forces shaping the Golgi glycosylation machinery: why cell surface glycans are universal to living cells. Cold Spring Harb Perspect Biol. 2011; 3(6). PMC: 3098673. DOI: 10.1101/cshperspect.a005462. View

Chen Q, Davis K . The potential of plants as a system for the development and production of human biologics. F1000Res. 2016; 5. PMC: 4876878. DOI: 10.12688/f1000research.8010.1. View

Yang Z, Wang S, Halim A, Schulz M, Frodin M, Rahman S . Engineered CHO cells for production of diverse, homogeneous glycoproteins. Nat Biotechnol. 2015; 33(8):842-4. DOI: 10.1038/nbt.3280. View

10.

Castilho A, Strasser R, Stadlmann J, Grass J, Jez J, Gattinger P . In planta protein sialylation through overexpression of the respective mammalian pathway. J Biol Chem. 2010; 285(21):15923-30. PMC: 2871460. DOI: 10.1074/jbc.M109.088401. View

11.

Kallolimath S, Castilho A, Strasser R, Grunwald-Gruber C, Altmann F, Strubl S . Engineering of complex protein sialylation in plants. Proc Natl Acad Sci U S A. 2016; 113(34):9498-503. PMC: 5003249. DOI: 10.1073/pnas.1604371113. View

12.

Constantinou A, Epenetos A, Hreczuk-Hirst D, Jain S, Wright M, Chester K . Site-specific polysialylation of an antitumor single-chain Fv fragment. Bioconjug Chem. 2009; 20(5):924-31. DOI: 10.1021/bc8005122. View

13.

Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T . Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol. 2016; 17(9):1102-8. PMC: 4994874. DOI: 10.1038/ni.3515. View

14.

Hamilton S, Davidson R, Sethuraman N, Nett J, Jiang Y, Rios S . Humanization of yeast to produce complex terminally sialylated glycoproteins. Science. 2006; 313(5792):1441-3. DOI: 10.1126/science.1130256. View

15.

Colley K, Kitajima K, Sato C . Polysialic acid: biosynthesis, novel functions and applications. Crit Rev Biochem Mol Biol. 2014; 49(6):498-532. DOI: 10.3109/10409238.2014.976606. View