Hedgehog Signalling in the Embryonic Mouse Thymus

Overview

Journal J Dev Biol

Specialty Biology

Date 2016 Aug 10

PMID 27504268

Citations 7

Authors

Alessandro Barbarulo

Ching-In Lau

Konstantinos Mengrelis

Susan Ross

Anisha Solanki

Jose Ignacio Saldana

Tessa Crompton

Affiliations

Soon will be listed here.

Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

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Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of .

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