Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity

Overview

Journal Bull Exp Biol Med

Publisher Springer

Specialty General Medicine

Date 2016 Aug 10

PMID 27502534

Citations 4

Authors

N E Sharanova

N V Kirbaeva

I Yu Toropygin

E V Khryapova

E V Koplik

C Kh Soto

S S Pertsov

a V Vasiliev

Affiliations

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Abstract

We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.

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