New Antifungal Agents and New Formulations Against Dermatophytes

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2016 Aug 10

PMID 27502503

Citations 53

Authors

Aditya K Gupta

Kelly A Foley

Sarah G Versteeg

Affiliations

Soon will be listed here.

Abstract

A variety of oral and topical antifungal agents are available for the treatment of superficial fungal infections caused by dermatophytes. This review builds on the antifungal therapy update published in this journal for the first special issue on Dermatophytosis (Gupta and Cooper 2008;166:353-67). Since 2008, there have not been additions to the oral antifungal armamentarium, with terbinafine, itraconazole, and fluconazole still in widespread use, albeit for generally more severe or recalcitrant infections. Griseofulvin is used in the treatment of tinea capitis. Oral ketoconazole has fallen out of favor in many jurisdictions due to risks of hepatotoxicity. Topical antifungals, applied once or twice daily, are the primary treatment for tinea pedis, tinea corporis/tinea cruris, and mild cases of tinea unguium. Newer topical antifungal agents introduced include the azoles, efinaconazole, luliconazole, and sertaconazole, and the oxaborole, tavaborole. Research is focused on developing formulations of existing topical antifungals that utilize novel delivery systems in order to enhance treatment efficacy and compliance.

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References

Shivamurthy R, Reddy S, Kallappa R, Somashekar S, Patil D, Patil U . Comparison of topical anti- fungal agents sertaconazole and clotrimazole in the treatment of tinea corporis-an observational study. J Clin Diagn Res. 2014; 8(9):HC09-12. PMC: 4225907. DOI: 10.7860/JCDR/2014/10210.4866. View

Rosen T . Mycological Considerations in the Topical Treatment of Superficial Fungal Infections. J Drugs Dermatol. 2016; 15(2 Suppl):s49-55. View

Gupta A, Studholme C . Novel investigational therapies for onychomycosis: an update. Expert Opin Investig Drugs. 2016; 25(3):297-305. DOI: 10.1517/13543784.2016.1142529. View

Monk J, Brogden R . Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1991; 42(4):659-72. DOI: 10.2165/00003495-199142040-00008. View

Panackal A, Halpern E, Watson A . Cutaneous fungal infections in the United States: Analysis of the National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS), 1995-2004. Int J Dermatol. 2009; 48(7):704-12. DOI: 10.1111/j.1365-4632.2009.04025.x. View

Jarratt M, Jones T, Adelglass J, Bucko A, Pollak R, Roman-Miranda A . Efficacy and safety of once-daily luliconazole 1% cream in patients ≥12 years of age with interdigital tinea pedis: a phase 3, randomized, double-blind,vehicle-controlled study. J Drugs Dermatol. 2014; 13(7):838-46. View

Mebazaa A, Oumari K, Ghariani N, Mili A, Belajouza C, Nouira R . Tinea capitis in adults in Tunisia. Int J Dermatol. 2010; 49(5):513-6. DOI: 10.1111/j.1365-4632.2010.04296.x. View

Choudhary S, Aghi T, Bisati S . Efficacy and safety of terbinafine hydrochloride 1% cream vs eberconazole nitrate 1% cream in localised tinea corporis and tinea cruris. Indian Dermatol Online J. 2014; 5(2):128-31. PMC: 4030336. DOI: 10.4103/2229-5178.131079. View

Sais G, Jucgla A, PEYRI J . Prevalence of dermatophyte onychomycosis in Spain: a cross-sectional study. Br J Dermatol. 1995; 132(5):758-61. DOI: 10.1111/j.1365-2133.1995.tb00722.x. View

10.

Abdel-Rahman S, Herron J, Fallon-Friedlander S, Hauffe S, Horowitz A, Riviere G . Pharmacokinetics of terbinafine in young children treated for tinea capitis. Pediatr Infect Dis J. 2005; 24(10):886-91. DOI: 10.1097/01.inf.0000180577.29853.a0. View

11.

Gupta A, Cooper E, Ryder J, Nicol K, Chow M, Chaudhry M . Optimal management of fungal infections of the skin, hair, and nails. Am J Clin Dermatol. 2004; 5(4):225-37. DOI: 10.2165/00128071-200405040-00003. View

12.

Nweze E, Eke I . Dermatophytosis in northern Africa. Mycoses. 2015; 59(3):137-44. DOI: 10.1111/myc.12447. View

13.

Ilkit M, Durdu M . Tinea pedis: the etiology and global epidemiology of a common fungal infection. Crit Rev Microbiol. 2014; 41(3):374-88. DOI: 10.3109/1040841X.2013.856853. View

14.

Allen H, Honig P, Leyden J, McGinley K . Selenium sulfide: adjunctive therapy for tinea capitis. Pediatrics. 1982; 69(1):81-3. View

15.

Elewski B . Tinea capitis: a current perspective. J Am Acad Dermatol. 1999; 42(1 Pt 1):1-20; quiz 21-4. DOI: 10.1016/s0190-9622(00)90001-x. View

16.

Murmu S, Debnath C, Pramanik A, Mitra T, Jana S, Dey S . Detection and characterization of zoonotic dermatophytes from dogs and cats in and around Kolkata. Vet World. 2016; 8(9):1078-82. PMC: 4774776. DOI: 10.14202/vetworld.2015.1078-1082. View

17.

van Zuuren E, Fedorowicz Z, El-Gohary M . Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review. Br J Dermatol. 2014; 172(3):616-41. DOI: 10.1111/bjd.13441. View

18.

Gupta A, Drummond-Main C, Cooper E, Brintnell W, Piraccini B, Tosti A . Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. J Am Acad Dermatol. 2011; 66(3):494-502. DOI: 10.1016/j.jaad.2011.02.038. View

19.

Croxtall J, Plosker G . Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009; 69(3):339-59. DOI: 10.2165/00003495-200969030-00009. View

20.

Gupta A, Skinner A, Cooper E . Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double-blind, placebo-controlled trial. Int J Dermatol. 2005; 44(7):590-3. DOI: 10.1111/j.1365-4632.2004.02559.x. View