Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

Overview

Journal Stem Cell Reports

Publisher Cell Press

Specialty Cell Biology

Date 2016 Aug 9

PMID 27499199

Citations 56

Authors

Carolyn A de Graaf

Jarny Choi

Tracey M Baldwin

Jessica E Bolden

Kirsten A Fairfax

Aaron J Robinson

Christine Biben

Clare Morgan

Kerry Ramsay

Ashley P Ng

Maria Kauppi

Elizabeth A Kruse

Tobias J Sargeant

Nick Seidenman

Angela DAmico

Marthe C DOmbrain

Erin C Lucas

Sandra Koernig

Adriana Baz Morelli

Michael J Wilson

Steven K Dower

Brenda Williams

Shen Y Heazlewood

Yifang Hu

Susan K Nilsson

Li Wu

Gordon K Smyth

Warren S Alexander

Douglas J Hilton

Affiliations

Soon will be listed here.

Abstract

Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.

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