Helicobacter Pylori Infection and Risk of Gastric Cancer in Korea: A Quantitative Systematic Review

Overview

Journal J Prev Med Public Health

Specialty Public Health

Date 2016 Aug 9

PMID 27499162

Citations 13

Authors

Jong-Myon Bae

Eun Hee Kim

Affiliations

Soon will be listed here.

Abstract

Objectives: In the context of the global decrease in mortality due to gastric cancer, previous studies have reported that the effect of chronic Helicobacter pylori (H. pylori) infection on the incidence of gastric cancer varies among regions. This systematic review was conducted to investigate H. pylori as a risk factor for gastric cancer in Korea, where the incidence of gastric cancer is among the highest in the world.

Methods: A search strategy was established to identify articles published in Korean as well as in English. Ultimately, we included observational studies conducted among Korean patients that designed with an age-matched and sex-matched control group that reported the odds ratio associated with H. pylori. Gastric cancer cases were subdivided into overall (OGC), cardia (CGC), non-cardia (NGC), early (EGC), advanced, intestinal (IGC), and diffuse forms of gastric cancer. Summary odds ratios (SORs) with 95% confidence intervals (CIs) were calculated in the meta-analysis using a random-effect model.

Results: Eleven case-control studies were ultimately selected. H. pylori was associated with an SOR of 1.81 (95% CI, 1.29 to 2.54) for OGC. Additionally, statistically significant risks were observed for CGC, NGC, EGC, and IGC.

Conclusions: Chronic H. pylori infection was found to raise the risk of gastric cancer among Koreans, with the highest risk observed for CGC and EGC (SOR=2.88 for both). Follow-up clinical epidemiologic studies are needed to assess the effects of current treatments aimed at eradicating H. pylori infections.

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References

Hansen S, Vollset S, Derakhshan M, Fyfe V, Melby K, Aase S . Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut. 2007; 56(7):918-25. PMC: 1994366. DOI: 10.1136/gut.2006.114504. View

Kim N, Park Y, Cho S, Lee H, Choe G, Kim I . Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter. 2008; 13(4):245-55. DOI: 10.1111/j.1523-5378.2008.00604.x. View

Kim J, Lee H, Kim N, Shin C, Lee S, Park Y . Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. Helicobacter. 2012; 17(5):358-68. DOI: 10.1111/j.1523-5378.2012.00958.x. View

Kim D, Lee M, Kim Y, Kim D, Bae J, Shin M . Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori. Eur J Epidemiol. 2005; 20(1):67-71. DOI: 10.1007/s10654-004-1027-y. View

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

Brenner H, Arndt V, Stegmaier C, Ziegler H, Rothenbacher D . Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer?. Am J Epidemiol. 2004; 159(3):252-8. DOI: 10.1093/aje/kwh039. View

Bae J, Kim E . Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review. J Prev Med Public Health. 2015; 48(5):225-30. PMC: 4592023. DOI: 10.3961/jpmph.15.046. View

Wroblewski L, Peek Jr R, Wilson K . Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010; 23(4):713-39. PMC: 2952980. DOI: 10.1128/CMR.00011-10. View

Harbord R, Egger M, Sterne J . A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med. 2005; 25(20):3443-57. DOI: 10.1002/sim.2380. View

10.

Parkin D . The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006; 118(12):3030-44. DOI: 10.1002/ijc.21731. View

11.

Ko K, Park S, Park B, Yang J, Cho L, Kang C . Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort. Cancer Epidemiol Biomarkers Prev. 2010; 19(5):1292-300. DOI: 10.1158/1055-9965.EPI-09-1004. View

12.

Correa P . Helicobacter pylori and gastric cancer: state of the art. Cancer Epidemiol Biomarkers Prev. 1996; 5(6):477-81. View

13.

. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001; 49(3):347-53. PMC: 1728434. DOI: 10.1136/gut.49.3.347. View

14.

Ko K, Park S, Cho L, Gwack J, Yang J, Shin A . Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk. J Nutr. 2009; 139(5):1008-12. DOI: 10.3945/jn.108.101865. View

15.

Huang J, Zheng G, Sumanac K, Irvine E, Hunt R . Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology. 2004; 125(6):1636-44. DOI: 10.1053/j.gastro.2003.08.033. View

16.

Lee B, Jang J, Kim J, You Y, Chun S, Kim H . Association of Helicobacter pylori infection with gastric adenocarcinoma. Jpn J Cancer Res. 1998; 89(6):597-603. PMC: 5921873. DOI: 10.1111/j.1349-7006.1998.tb03260.x. View

17.

Cho S, Choi I, Kim C, Kook M, Lee J, Kim B . Risk factors associated with gastric cancer in patients with a duodenal ulcer. Helicobacter. 2010; 15(6):516-23. DOI: 10.1111/j.1523-5378.2010.00805.x. View

18.

Cavaleiro-Pinto M, Peleteiro B, Lunet N, Barros H . Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. Cancer Causes Control. 2010; 22(3):375-87. DOI: 10.1007/s10552-010-9707-2. View

19.

Hwang J, Lee D, Lee A, Yoon H, Shin C, Park Y . Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection. World J Gastroenterol. 2015; 21(16):4954-60. PMC: 4408468. DOI: 10.3748/wjg.v21.i16.4954. View

20.

Kim H, Lee S, Choi B, Kim M . Nitrate intake relative to antioxidant vitamin intake affects gastric cancer risk: a case-control study in Korea. Nutr Cancer. 2007; 59(2):185-91. DOI: 10.1080/01635580701460554. View