Regrowth of Serotonin Axons in the Adult Mouse Brain Following Injury

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2016 Aug 9

PMID 27499084

Citations 42

Authors

Yunju Jin

Sarah E Dougherty

Kevin Wood

Landy Sun

Robert H Cudmore

Aya Abdalla

Geetha Kannan

Mikhail Pletnikov

Parastoo Hashemi

David J Linden

Affiliations

Soon will be listed here.

Abstract

It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury. Studies using fixed tissue have suggested that serotonin neurons might be a notable exception, but remain inconclusive. We have employed in vivo two-photon microscopy to produce time-lapse images of serotonin axons in the neocortex of the adult mouse. Serotonin axons undergo massive retrograde degeneration following amphetamine treatment and subsequent slow recovery of axonal density, which is dominated by new growth with little contribution from local sprouting. A stab injury that transects serotonin axons running in the neocortex is followed by local regression of cut serotonin axons and followed by regrowth from cut ends into and across the stab rift zone. Regrowing serotonin axons do not follow the pathways left by degenerated axons. The regrown axons release serotonin and their regrowth is correlated with recovery in behavioral tests.

Citing Articles

Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury.

Cooke P, Linden D eNeuro. 2024; 12(1.

PMID: 39725517 PMC: 11729145. DOI: 10.1523/ENEURO.0418-24.2024.

Chronic Treatment with Serotonin Selective Reuptake Inhibitors Does Not Affect Regrowth of Serotonin Axons Following Amphetamine Injury in the Mouse Forebrain.

Janowitz H, Linden D eNeuro. 2024; 11(2).

PMID: 38355299 PMC: 10867722. DOI: 10.1523/ENEURO.0444-22.2023.

Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System.

OConnell C, Brown R, Peach T, Traubert O, Schwierling H, Notorgiacomo G Brain Sci. 2024; 14(1).

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An experimental platform for stochastic analyses of single serotonergic fibers in the mouse brain.

Mays K, Haiman J, Janusonis S Front Neurosci. 2023; 17:1241919.

PMID: 37869509 PMC: 10587471. DOI: 10.3389/fnins.2023.1241919.

Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration.

Kim H, Saikia J, Monte K, Ha E, Romaus-Sanjurjo D, Sanchez J Neuron. 2023; 111(24):3953-3969.e5.

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