Longitudinal Effects of Developmental Bisphenol A and Variable Diet Exposures on Epigenetic Drift in Mice

Overview

Journal Reprod Toxicol

Specialties Reproductive Medicine
Toxicology

Date 2016 Aug 7

PMID 27496716

Citations 25

Authors

Joseph Kochmanski

Elizabeth H Marchlewicz

Matthew Savidge

Luke Montrose

Christopher Faulk

Dana C Dolinoy

Affiliations

Soon will be listed here.

Abstract

Environmental factors, including exogenous exposures and nutritional status, can affect DNA methylation across the epigenome, but effects of exposures on age-dependent epigenetic drift remain unclear. Here, we tested the hypothesis that early-life exposure to bisphenol A (BPA) and/or variable diet results in altered epigenetic drift, as measured longitudinally via target loci methylation in paired mouse tail tissue (3 wks/10 mos old). Methylation was quantified at two repetitive elements (LINE-1, IAP), two imprinted genes (Igf2, H19), and one non-imprinted gene (Esr1) in isogenic mice developmentally exposed to Control, Control+BPA (50μg/kg diet), Mediterranean, Western, Mediterranean+BPA, or Western+BPA diets. Across age, methylation levels significantly (p<0.050) decreased at LINE-1, IAP, and H19, and increased at Esr1. Igf2 demonstrated Western-specific changes in early-life methylation (p=0.027), and IAP showed marginal negative modification of drift in Western (p=0.058) and Western+BPA (p=0.051). Thus, DNA methylation drifts across age, and developmental nutritional exposures can alter age-related methylation patterns.

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