Incidence and Excess Mortality of Hip Fracture in Young Adults: a Nationwide Population-based Cohort Study

Overview

Journal BMC Musculoskelet Disord

Publisher Biomed Central

Specialties Orthopedics
Physiology

Date 2016 Aug 7

PMID 27496130

Citations 4

Authors

Tsai-Hsueh Leu

Wei-Chun Chang

Jeff Chien-Fu Lin

Chi Lo

Wen-Miin Liang

Yu-Jun Chang

Dann-Pyng Shih

Cheng-Chun Wu

Chi-Fung Cheng

Sy-Jye Wei

Affiliations

Soon will be listed here.

Abstract

Background: This study assessed the incidence and excess mortality of hip fractures among inpatients aged 20-40 years in a nationwide population database in Taiwan.

Methods: Subjects were selected from Taiwan's National Health Insurance Research Database for the period 2001-2008 and were followed up until the end of 2010. A total of 4,523 subjects were admitted for the first time with primary diagnosis of hip fracture and treated with operation.

Results: The overall annual incidence, mortality, and standardized mortality ratio (SMR) decreased from 7.68 to 7.23 per 100,000, from 1.37 % to 0.94 %, and from 9.06 to 6.71, respectively, from 2001 to 2008. The 1-year, 2-year, 3-year, 5-year, and 10-year mortality rates were 1.28 %, 2.44 %, 3.54 %, 5.32 %, and 10.50 %, respectively for the whole cohort. The 1-year, 2-year, 3-year, 5-year, and 10-year SMRs were 8.33, 7.59, 7.28, 6.39, and 5.82, respectively, for the whole cohort. Risk factors for overall death were male gender, trochanteric fracture, hemiarthroplasty, and higher Charlson comorbidity index (CCI) scores.

Conclusions: The high SMRs found in the present study suggest that young adults with former hip fracture should be closely followed up to prevent early mortality.

Citing Articles

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References

Wolinsky F, Fitzgerald J, Stump T . The effect of hip fracture on mortality, hospitalization, and functional status: a prospective study. Am J Public Health. 1997; 87(3):398-403. PMC: 1381011. DOI: 10.2105/ajph.87.3.398. View

Yoon H, Park C, Jang S, Jang S, Lee Y, Ha Y . Incidence and mortality following hip fracture in Korea. J Korean Med Sci. 2011; 26(8):1087-92. PMC: 3154346. DOI: 10.3346/jkms.2011.26.8.1087. View

Panula J, Pihlajamaki H, Mattila V, Jaatinen P, Vahlberg T, Aarnio P . Mortality and cause of death in hip fracture patients aged 65 or older: a population-based study. BMC Musculoskelet Disord. 2011; 12:105. PMC: 3118151. DOI: 10.1186/1471-2474-12-105. View

Kanis J, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby A . The components of excess mortality after hip fracture. Bone. 2003; 32(5):468-73. DOI: 10.1016/s8756-3282(03)00061-9. View

Kim S, Meehan J, Blumenfeld T, Szabo R . Hip fractures in the United States: 2008 nationwide emergency department sample. Arthritis Care Res (Hoboken). 2011; 64(5):751-7. DOI: 10.1002/acr.21580. View

Tosteson A, Gottlieb D, Radley D, Fisher E, Melton 3rd L . Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int. 2007; 18(11):1463-72. PMC: 2729704. DOI: 10.1007/s00198-007-0429-6. View

Zuckerman J . Hip fracture. N Engl J Med. 1996; 334(23):1519-25. DOI: 10.1056/NEJM199606063342307. View

Radley D, Gottlieb D, Fisher E, Tosteson A . Comorbidity risk-adjustment strategies are comparable among persons with hip fracture. J Clin Epidemiol. 2008; 61(6):580-7. PMC: 2653048. DOI: 10.1016/j.jclinepi.2007.08.001. View

Hagino H, Furukawa K, Fujiwara S, Okano T, Katagiri H, Yamamoto K . Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan. Osteoporos Int. 2008; 20(4):543-8. DOI: 10.1007/s00198-008-0685-0. View

10.

Boden S, Labropoulos P, Saunders R . Hip fractures in young patients: is this early osteoporosis?. Calcif Tissue Int. 1990; 46(2):65-72. DOI: 10.1007/BF02556089. View

11.

Swiontkowski M, Winquist R, Hansen Jr S . Fractures of the femoral neck in patients between the ages of twelve and forty-nine years. J Bone Joint Surg Am. 1984; 66(6):837-46. DOI: 10.2106/00004623-198466060-00003. View

12.

Lofthus C, Osnes E, Meyer H, Kristiansen I, Nordsletten L, Falch J . Young patients with hip fracture: a population-based study of bone mass and risk factors for osteoporosis. Osteoporos Int. 2006; 17(11):1666-72. DOI: 10.1007/s00198-006-0176-0. View

13.

Karantana A, Boulton C, Bouliotis G, Shu K, Scammell B, Moran C . Epidemiology and outcome of fracture of the hip in women aged 65 years and under: a cohort study. J Bone Joint Surg Br. 2011; 93(5):658-64. DOI: 10.1302/0301-620X.93B5.24536. View

14.

Icks A, Haastert B, Wildner M, Becker C, Meyer G . Trend of hip fracture incidence in Germany 1995-2004: a population-based study. Osteoporos Int. 2007; 19(8):1139-45. DOI: 10.1007/s00198-007-0534-6. View

15.

Tenenhouse A, Joseph L, Kreiger N, Poliquin S, Murray T, Blondeau L . Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int. 2001; 11(10):897-904. DOI: 10.1007/s001980070050. View

16.

Wu T, Jen M, Bottle A, Liaw C, Aylin P, Majeed A . Admission rates and in-hospital mortality for hip fractures in England 1998 to 2009: time trends study. J Public Health (Oxf). 2010; 33(2):284-91. DOI: 10.1093/pubmed/fdq074. View

17.

Cummings S, Melton L . Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359(9319):1761-7. DOI: 10.1016/S0140-6736(02)08657-9. View

18.

Duckworth A, Bennet S, Aderinto J, Keating J . Fixation of intracapsular fractures of the femoral neck in young patients: risk factors for failure. J Bone Joint Surg Br. 2011; 93(6):811-6. DOI: 10.1302/0301-620X.93B6.26432. View

19.

Aggarwal N, Raveendran A, Khandelwal N, Sen R, Thakur J, Dhaliwal L . Prevalence and related risk factors of osteoporosis in peri- and postmenopausal Indian women. J Midlife Health. 2012; 2(2):81-5. PMC: 3296391. DOI: 10.4103/0976-7800.92537. View

20.

Bjorgul K, Reikeras O . Incidence of hip fracture in southeastern Norway: a study of 1,730 cervical and trochanteric fractures. Int Orthop. 2006; 31(5):665-9. PMC: 2266638. DOI: 10.1007/s00264-006-0251-3. View