Antimalarial Potential of Leaves of Chenopodium Ambrosioides L

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2016 Aug 6

PMID 27492200

Citations 8

Authors

Dalila Nunes Cysne

Thiare Silva Fortes

Aramys Silva Reis

Bruno de Paulo Ribeiro

Amalia Dos Santos Ferreira

Flavia Maria Mendonca do Amaral

Rosane Nassar Meireles Guerra

Claudio Romero Farias Marinho

Roberto Nicolete

Flavia Raquel Fernandes Nascimento

Affiliations

Soon will be listed here.

Abstract

In an effort to identify novel therapeutic alternatives for the treatment of malaria, the present study evaluated the antimalarial effect of the crude hydroalcoholic extract (HCE) from the leaves of Chenopodium ambrosioides L. For this purpose, the molecular affinity between the total proteins from erythrocytes infected with Plasmodium falciparum and HCE or chloroquine was evaluated by surface plasmon resonance (SPR). Subsequently, the plasmodicidal potential of HCE was assessed in a P. falciparum culture. Using BALB/c mice infected with Plasmodium berghei intraperitoneally (ip.), we evaluated the effects of ip. treatment, for three consecutive days (day 7, 8, and 9 after infection), with chloroquine (45 mg/kg) or HCE (5 mg/kg), considering the survival index and the parasitaemia. The groups were compared to an untreated control group that receives only PBS at the same periods. The results indicated that HCE could bind to the total proteins of infected erythrocytes and could inhibit the parasite growth in vitro (IC = 25.4 g/mL). The in vivo therapeutic treatment with HCE increased the survival and decreased the parasitaemia in the infected animals. Therefore, the HCE treatment exhibited a significant antiplasmodial effect and may be considered as a potential candidate for the development of new antimalarial drugs.

Citing Articles

The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria.

Bourgeois A, Lemos J, Roucheray S, Sergerie A, Richard D Infect Dis Rep. 2024; 16(4):543-560.

PMID: 39051241 PMC: 11270350. DOI: 10.3390/idr16040041.

Chemical Composition and Antiplasmodial Activity of the Essential Oil of Leaves from Nunavik, Québec, Canada.

Seguin J, Gagnon D, Belanger S, Richard D, Fernandez X, Boudreau S ACS Omega. 2023; 8(19):16729-16737.

PMID: 37214733 PMC: 10193425. DOI: 10.1021/acsomega.3c00235.

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review.

Rodrigues M, Pereira C, Oliveira M, Zengin G, Custodio L Mar Drugs. 2023; 21(2).

PMID: 36827107 PMC: 9967096. DOI: 10.3390/md21020066.

Antibacterial and Antioxidant Activity of (L.) Mosyakin and Clemants Essential Oils: Experimental and Computational Approaches.

Kandsi F, Elbouzidi A, Zahra Lafdil F, Meskali N, Azghar A, Addi M Antibiotics (Basel). 2022; 11(4).

PMID: 35453233 PMC: 9031865. DOI: 10.3390/antibiotics11040482.

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology.

Ceravolo I, Aguiar A, Adebayo J, Krettli A Front Pharmacol. 2021; 12:734263.

PMID: 34630109 PMC: 8493299. DOI: 10.3389/fphar.2021.734263.

References

Nascimento F, Cruz G, Pereira P, Maciel M, Silva L, Azevedo A . Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment. Life Sci. 2005; 78(22):2650-3. DOI: 10.1016/j.lfs.2005.10.006. View

Monzote L, Garcia M, Pastor J, Gil L, Scull R, Maes L . Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms. Exp Parasitol. 2013; 136:20-6. DOI: 10.1016/j.exppara.2013.10.007. View

Liu J, Modrek S, Gosling R, Feachem R . Malaria eradication: is it possible? Is it worth it? Should we do it?. Lancet Glob Health. 2014; 1(1):e2-3. DOI: 10.1016/S2214-109X(13)70002-0. View

TrivellatoGrassi L, Malheiros A, Meyre-Silva C, da Silva Buss Z, Monguilhott E, Frode T . From popular use to pharmacological validation: a study of the anti-inflammatory, anti-nociceptive and healing effects of Chenopodium ambrosioides extract. J Ethnopharmacol. 2012; 145(1):127-38. DOI: 10.1016/j.jep.2012.10.040. View

Hanum P S, Hayano M, Kojima S . Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: early chemokine expression in the brain. Int Immunol. 2003; 15(5):633-40. DOI: 10.1093/intimm/dxg065. View

Oliveira A, Dolabela M, Braga F, Jacome R, Varotti F, Povoa M . Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids. An Acad Bras Cienc. 2009; 81(4):715-40. DOI: 10.1590/s0001-37652009000400011. View

Reis P, Estato V, da Silva T, dAvila J, Siqueira L, Assis E . Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. PLoS Pathog. 2013; 8(12):e1003099. PMC: 3531520. DOI: 10.1371/journal.ppat.1003099. View

Cui L, Su X . Discovery, mechanisms of action and combination therapy of artemisinin. Expert Rev Anti Infect Ther. 2009; 7(8):999-1013. PMC: 2778258. DOI: 10.1586/eri.09.68. View

Franca F, Lago E, Marsden P . Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil. Rev Soc Bras Med Trop. 1996; 29(3):229-32. DOI: 10.1590/s0037-86821996000300002. View

10.

Batista R, Silva Jr A, Braga de Oliveira A . Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. Molecules. 2009; 14(8):3037-72. PMC: 6254980. DOI: 10.3390/molecules14083037. View

11.

Jordao F, Saito A, Miguel D, de Jesus Peres V, Kimura E, Katzin A . In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011; 55(5):2026-31. PMC: 3088194. DOI: 10.1128/AAC.01820-10. View

12.

TRAGER W, Jensen J . Human malaria parasites in continuous culture. Science. 1976; 193(4254):673-5. DOI: 10.1126/science.781840. View

13.

Janse C, van Vianen P . Flow cytometry in malaria detection. Methods Cell Biol. 1994; 42 Pt B:295-318. DOI: 10.1016/s0091-679x(08)61081-x. View

14.

Fitch C . Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004; 74(16):1957-72. DOI: 10.1016/j.lfs.2003.10.003. View

15.

Dolabela M, Oliveira S, Nascimento J, Peres J, Wagner H, Povoa M . In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. Phytomedicine. 2008; 15(5):367-72. DOI: 10.1016/j.phymed.2008.02.001. View

16.

Munoz V, Sauvain M, Bourdy G, Callapa J, Bergeron S, Rojas I . A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians. J Ethnopharmacol. 2000; 69(2):127-37. DOI: 10.1016/s0378-8741(99)00148-8. View

17.

Bienvenu A, Picot S . Statins alone are ineffective in cerebral malaria but potentiate artesunate. Antimicrob Agents Chemother. 2008; 52(11):4203-4. PMC: 2573154. DOI: 10.1128/AAC.00513-08. View

18.

Hyde J . Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs. Microbes Infect. 2002; 4(2):165-74. DOI: 10.1016/s1286-4579(01)01524-6. View

19.

Conway G, SLOCUMB J . Plants used as abortifacients and emmenagogues by Spanish New Mexicans. J Ethnopharmacol. 1979; 1(3):241-61. DOI: 10.1016/s0378-8741(79)80014-8. View

20.

Cruz G, Pereira P, Patricio F, Costa G, Sousa S, Frazao J . Increase of cellular recruitment, phagocytosis ability and nitric oxide production induced by hydroalcoholic extract from Chenopodium ambrosioides leaves. J Ethnopharmacol. 2006; 111(1):148-54. DOI: 10.1016/j.jep.2006.11.006. View