Invasive Micropapillary Carcinoma of the Breast Had Poor Clinical Characteristics but Showed No Difference in Prognosis Compared with Invasive Ductal Carcinoma

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2016 Aug 6

PMID 27492008

Citations 12

Authors

Guanqiao Li

Shiping Yang

Jia Yao

Zhenping Wang

Guangyu Yao

Mingfeng Liu

Changsheng Ye

Affiliations

Soon will be listed here.

Abstract

Background: It is controversial for prognosis of invasive micropapillary carcinoma (IMPC) compared with invasive ductal carcinoma (IDC) of the breast. To better understand the difference between IMPC and IDC prognoses, we conducted this retrospective study.

Methods: Data from 33 patients with IMPC were retrospectively reviewed, and the clinicopathologic characteristics and survival status were compared with those of 347 patients with IDC who were treated during the same period.

Results: The IMPC cases were of larger tumor size, greater proportion of nodal involvement, and an increased incidence of lymphovascular invasion compared with IDC cases. The overall survival (OS), local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and failure-free survival (FFS) rates were not significantly different between IMPC and IDC. The 3-year OS rate was 97 vs 94.2 % for the IMPC and IDC patients, respectively. The 3-year FFS rate was 87.9 vs 86.2 % for the IMPC and IDC patients, respectively. For IMPC patients, the 3-year LRFS rate was 93.9 % and in IDC patients was 89.0 %. The 3-year DMFS rates of IMPC patients was 90.9 % and IDC patients was 89 %.

Conclusions: IMPC had poor clinical characteristics, but it showed no difference in OS, FFS, LRFS, and DMFS compare with IDC.

Citing Articles

Invasive micropapillary carcinoma of the breast and invasive breast carcinoma of no special type: a comparison of claudin proteins' expression and its impact on survival.

Kramer Z, Budai A, Pesti A, Kulka J, Tokes A Pathol Oncol Res. 2024; 30:1611987.

PMID: 39687048 PMC: 11646764. DOI: 10.3389/pore.2024.1611987.

A prognostic nomogram based on risk assessment for invasive micropapillary carcinoma of the breast after surgery.

Chen Y, Yu C, Chen D, Tang Y, Zhu K, Guo R Cancer Med. 2023; 12(7):8050-8062.

PMID: 36602294 PMC: 10134302. DOI: 10.1002/cam4.5595.

COX-2 expression in mammary invasive micropapillary carcinoma is associated with prognostic factors and acts as a potential therapeutic target in comparative oncology.

Vieira T, Oliveira E, Jaime Dos Santos B, Souza F, Veloso E, Nunes C Front Vet Sci. 2022; 9:983110.

PMID: 36172611 PMC: 9510711. DOI: 10.3389/fvets.2022.983110.

A rare case of invasive micropapillary carcinoma of the breast.

Verras G, Mulita F, Tchabashvili L, Grypari I, Sourouni S, Panagodimou E Prz Menopauzalny. 2022; 21(1):73-80.

PMID: 35388282 PMC: 8966417. DOI: 10.5114/pm.2022.113834.

Micropapillary Breast Carcinoma: From Molecular Pathogenesis to Prognosis.

Verras G, Tchabashvili L, Mulita F, Grypari I, Sourouni S, Panagodimou E Breast Cancer (Dove Med Press). 2022; 14:41-61.

PMID: 35310681 PMC: 8926414. DOI: 10.2147/BCTT.S346301.

References

Graham L, Shupe M, Schneble E, Flynt F, Clemenshaw M, Kirkpatrick A . Current approaches and challenges in monitoring treatment responses in breast cancer. J Cancer. 2014; 5(1):58-68. PMC: 3881221. DOI: 10.7150/jca.7047. View

Bocker W . [WHO classification of breast tumors and tumors of the female genital organs: pathology and genetics]. Verh Dtsch Ges Pathol. 2003; 86:116-9. View

Rodrigues M, Gamba C, Faria J, Ferreira E, Goes A, Gomes D . Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland. Pathol Res Pract. 2016; 212(4):340-4. PMC: 4834221. DOI: 10.1016/j.prp.2015.11.017. View

Liu Y, Huang X, Bi R, Yang W, Shao Z . Similar prognoses for invasive micropapillary breast carcinoma and pure invasive ductal carcinoma: a retrospectively matched cohort study in China. PLoS One. 2014; 9(9):e106564. PMC: 4154720. DOI: 10.1371/journal.pone.0106564. View

Chen A, Paulino A, Schwartz M, Rodriguez A, Bass B, Chang J . Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Br J Cancer. 2014; 111(3):619-22. PMC: 4119976. DOI: 10.1038/bjc.2014.301. View

Kuroda H, Sakamoto G, Ohnisi K, Itoyama S . Clinical and pathologic features of invasive micropapillary carcinoma. Breast Cancer. 2004; 11(2):169-74. DOI: 10.1007/BF02968297. View

Benson J, Jatoi I . The global breast cancer burden. Future Oncol. 2012; 8(6):697-702. DOI: 10.2217/fon.12.61. View

Siriaunkgul S, Tavassoli F . Invasive micropapillary carcinoma of the breast. Mod Pathol. 1993; 6(6):660-2. View

Gokce H, Guray Durak M, Akin M, Canda T, Balci P, Ellidokuz H . Invasive micropapillary carcinoma of the breast: a clinicopathologic study of 103 cases of an unusual and highly aggressive variant of breast carcinoma. Breast J. 2013; 19(4):374-81. DOI: 10.1111/tbj.12128. View

10.

Chen A, Paulino A, Schwartz M, Rodriguez A, Bass B, Chang J . Prognostic markers for invasive micropapillary carcinoma of the breast: a population-based analysis. Clin Breast Cancer. 2012; 13(2):133-9. DOI: 10.1016/j.clbc.2012.10.001. View

11.

Yu J, Choi D, Huh S, Cho E, Kim K, Chie E . Differences in Prognostic Factors and Failure Patterns Between Invasive Micropapillary Carcinoma and Carcinoma With Micropapillary Component Versus Invasive Ductal Carcinoma of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06). Clin Breast Cancer. 2015; 15(5):353-61.e1-2. DOI: 10.1016/j.clbc.2015.01.008. View

12.

Vingiani A, Maisonneuve P, DellOrto P, Farante G, Rotmensz N, Lissidini G . The clinical relevance of micropapillary carcinoma of the breast: a case-control study. Histopathology. 2013; 63(2):217-24. DOI: 10.1111/his.12147. View

13.

De La Cruz C, Moriya T, Endoh M, Watanabe M, Takeyama J, Yang M . Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study. Pathol Int. 2004; 54(2):90-6. DOI: 10.1111/j.1440-1827.2004.01590.x. View

14.

Yu J, Choi D, Park W, Huh S, Cho E, Lim Y . Differences in prognostic factors and patterns of failure between invasive micropapillary carcinoma and invasive ductal carcinoma of the breast: matched case-control study. Breast. 2010; 19(3):231-7. DOI: 10.1016/j.breast.2010.01.020. View

15.

Shi W, Yang L, Hu X, Zhou J, Zhang Q, Shao Z . Clinico-pathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma: a population-based study from China. PLoS One. 2014; 9(6):e101390. PMC: 4076314. DOI: 10.1371/journal.pone.0101390. View

16.

Luna-More S, de los Santos F, Breton J, Canadas M . Estrogen and progesterone receptors, c-erbB-2, p53, and Bcl-2 in thirty-three invasive micropapillary breast carcinomas. Pathol Res Pract. 1996; 192(1):27-32. DOI: 10.1016/S0344-0338(96)80126-9. View

17.

Singletary S, Allred C, Ashley P, Bassett L, Berry D, Bland K . Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am. 2003; 83(4):803-19. DOI: 10.1016/S0039-6109(03)00034-3. View

18.

Chen L, Fan Y, Lang R, Guo X, Sun Y, Cui L . Breast carcinoma with micropapillary features: clinicopathologic study and long-term follow-up of 100 cases. Int J Surg Pathol. 2008; 16(2):155-63. DOI: 10.1177/1066896907307047. View