The Initiation of Post-synaptic Protrusions

Overview

Journal Commun Integr Biol

Specialty Biology

Date 2016 Aug 5

PMID 27489575

Citations 1

Authors

Pirta Hotulainen

Juha Saarikangas

Affiliations

Soon will be listed here.

Abstract

The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions.

Citing Articles

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Montano-Rendon F, Grinstein S, Walpole G Front Cell Dev Biol. 2021; 9:626136.

PMID: 33614656 PMC: 7890364. DOI: 10.3389/fcell.2021.626136.

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