Epidemiology and Economic Burden of Measles, Mumps, Pertussis, and Varicella in Germany: a Systematic Review

Overview

Journal Int J Public Health

Specialty Public Health

Date 2016 Aug 5

PMID 27488917

Citations 18

Authors

Oliver Damm

Julian Witte

Stefanie Wetzka

Christine Prosser

Sebastian Braun

Robert Welte

Wolfgang Greiner

Affiliations

Soon will be listed here.

Abstract

Objectives: Despite the availability of vaccines and the existence of public vaccination recommendations, outbreaks of vaccine-preventable childhood diseases still cause public health debate. The objective of this systematic review was to provide an overview of the current epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany.

Methods: We systematically reviewed studies published since 2000. The literature search was conducted using PubMed and EMBASE. Also, we used German notification data to give an up-to-date overview of the epidemiology of the four diseases under consideration.

Results: Thirty-six studies were included in our review. Results suggest that there is still considerable morbidity due to childhood diseases in Germany. Studies providing cost estimates are scarce. Comparative analyses of different data sources (notification data vs. claims data) revealed a potential underestimation of incidence estimates when using notification data. Furthermore, several studies showed regional differences in incidence of some of the diseases under consideration.

Conclusions: Our findings underline the need for improved vaccination and communication strategies targeting all susceptible age and risk groups on a national and local level.

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References

Hellenbrand W, Beier D, Jensen E, Littmann M, Meyer C, Oppermann H . The epidemiology of pertussis in Germany: past and present. BMC Infect Dis. 2009; 9:22. PMC: 2653494. DOI: 10.1186/1471-2334-9-22. View

Voigt K, King N . Disability weights in the global burden of disease 2010 study: two steps forward, one step back?. Bull World Health Organ. 2014; 92(3):226-8. PMC: 3949595. DOI: 10.2471/BLT.13.126227. View

Arenz S, Fischer R, Wildner M . Measles outbreak in Germany: clinical presentation and outcome of children hospitalized for measles in 2006. Pediatr Infect Dis J. 2009; 28(11):1030-2. DOI: 10.1097/INF.0b013e3181aa6a29. View

Bisgard K, Pascual F, Ehresmann K, Miller C, Cianfrini C, Jennings C . Infant pertussis: who was the source?. Pediatr Infect Dis J. 2004; 23(11):985-9. DOI: 10.1097/01.inf.0000145263.37198.2b. View

Siedler A, Leitmeyer K . [Relevance of sentinel surveillance systems for the implementation and evaluation of vaccination strategies]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2004; 47(12):1136-43. DOI: 10.1007/s00103-004-0947-8. View

Gibbons C, Mangen M, Plass D, Havelaar A, Brooke R, Kramarz P . Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods. BMC Public Health. 2014; 14:147. PMC: 4015559. DOI: 10.1186/1471-2458-14-147. View

Juretzko P, Haastert B, Giani G, von Kries R, Wirsing von Konig C . Pertussis in Germany: regional differences in management and vaccination status of hospitalized cases. Epidemiol Infect. 2001; 127(1):63-71. PMC: 2869730. DOI: 10.1017/s0950268801005593. View

Mankertz A, Mihneva Z, Gold H, Baumgarte S, Baillot A, Helble R . Spread of measles virus D4-Hamburg, Europe, 2008-2011. Emerg Infect Dis. 2011; 17(8):1396-401. PMC: 3381563. DOI: 10.3201/eid1708.101994. View

Murray C, Ezzati M, Flaxman A, Lim S, Lozano R, Michaud C . GBD 2010: design, definitions, and metrics. Lancet. 2012; 380(9859):2063-6. DOI: 10.1016/S0140-6736(12)61899-6. View

10.

Plass D, Mangen M, Kraemer A, Pinheiro P, Gilsdorf A, Krause G . The disease burden of hepatitis B, influenza, measles and salmonellosis in Germany: first results of the burden of communicable diseases in Europe study. Epidemiol Infect. 2014; 142(10):2024-35. PMC: 9151280. DOI: 10.1017/S0950268813003312. View

11.

Wagenpfeil S, Neiss A, Banz K, Wutzler P . Empirical data on the varicella situation in Germany for vaccination decisions. Clin Microbiol Infect. 2004; 10(5):425-30. DOI: 10.1111/j.1469-0691.2004.00853.x. View

12.

Baptista P, Magalhaes V, Rodrigues L . The role of adults in household outbreaks of pertussis. Int J Infect Dis. 2009; 14(2):e111-4. DOI: 10.1016/j.ijid.2009.03.026. View

13.

Abu Sin M, Zenke R, Ronckendorf R, Littmann M, Jorgensen P, Hellenbrand W . Pertussis outbreak in primary and secondary schools in Ludwigslust, Germany demonstrating the role of waning immunity. Pediatr Infect Dis J. 2009; 28(3):242-4. DOI: 10.1097/INF.0b013e31818a5d69. View

14.

Takla A, Wichmann O, Klinc C, Hautmann W, Rieck T, Koch J . Mumps epidemiology in Germany 2007-11. Euro Surveill. 2013; 18(33):20557. DOI: 10.2807/1560-7917.es2013.18.33.20557. View

15.

Nitsch-Osuch A, Korzeniewski K, Kuchar E, Zielonka T, Zycinska K, Wardyn K . Epidemiological and immunological reasons for pertussis vaccination in adolescents and adults. Respir Physiol Neurobiol. 2013; 187(1):99-103. DOI: 10.1016/j.resp.2013.02.007. View

16.

Wichmann O, Siedler A, Sagebiel D, Hellenbrand W, Santibanez S, Mankertz A . Further efforts needed to achieve measles elimination in Germany: results of an outbreak investigation. Bull World Health Organ. 2009; 87(2):108-15. PMC: 2636188. DOI: 10.2471/blt.07.050187. View

17.

Muscat M, Bang H, Wohlfahrt J, Glismann S, Molbak K . Measles in Europe: an epidemiological assessment. Lancet. 2009; 373(9661):383-9. DOI: 10.1016/S0140-6736(08)61849-8. View

18.

Siedler A, Gruber A, Mankertz A . [Measles surveillance in Germany. From sentinel to mandatory surveillance]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013; 56(9):1321-8. DOI: 10.1007/s00103-013-1787-1. View

19.

Siedler A, Dettmann M . Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany. Hum Vaccin Immunother. 2014; 10(12):3594-600. PMC: 4514040. DOI: 10.4161/hv.34426. View

20.

Siedler A, Tischer A, Mankertz A, Santibanez S . Two outbreaks of measles in Germany 2005. Euro Surveill. 2006; 11(4):131-4. View