Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2016 Aug 5

PMID 27488743

Citations 60

Authors

Kenton M Sanders

Yoshihiko Kito

Sung Jin Hwang

Sean M Ward

Affiliations

Soon will be listed here.

Abstract

Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit(+) interstitial cells of Cajal and PDGFRα(+) cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.

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