Reversal of Tetracycline Resistance in Escherichia Coli by Noncytotoxic Bis(Tryptophan)s

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2016 Aug 4

PMID 27487320

Citations 8

Authors

Joseph W Meisel

Mohit B Patel

Evan Garrad

Ryan A Stanton

George W Gokel

Affiliations

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Abstract

Nine bis(tryptophan) derivatives (BTs) and two control compounds were synthesized and tested for antimicrobial activity against two Escherichia coli strains and a Staphylococcus aureus strain. The effects of linker type, shape, and conformational rigidity were manifested in dramatic differences in altering tetracycline potency when coadministered with that antibiotic. A reversal of resistance was observed for an E. coli strain having a TetA efflux pump. Survival of mammalian cells was assayed with good result.

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