LncRNA RSU1P2 Contributes to Tumorigenesis by Acting As a CeRNA Against Let-7a in Cervical Cancer Cells

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Aug 4

PMID 27487126

Citations 45

Authors

Qian Liu

Xu Guo

Shengshun Que

Xi Yang

Hongxia Fan

Min Liu

Xin Li

Hua Tang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) can regulate gene expression at different levels and are widely participate in various physiological and pathological processes. Emerging evidences suggests that a number of differentially expressed lncRNAs are involved in tumorigenesis. However, the function and expression regulation of a vast majority of these unique RNAs is little known. Here, we found that the lncRNA Ras suppressor protein 1 pseudogene 2 (RSU1P2) is upregulateded in cervical cancer tissues and has a tumour-promoting role. We revealed that RSU1P2 acts as a competitive endogenous RNA (ceRNA) through regulating the expression of IGF1R, N-myc and EphA4. The mechanism of this regulation is via competition for the shared microRNA let-7a. This competition promotes the malignant phenotype of cervical carcinoma cells. The transcription factor N-myc forms a positive feedback loop with RSU1P2 by in turn activating its expression, thereby enhancing its oncogenic capacity. Hence, cancer-selective targeting of RSU1P2 could have strong benefits.

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