Peripheral Sensory Neuropathy is Associated with Altered Postocclusive Reactive Hyperemia in the Diabetic Foot

Overview

Journal BMJ Open Diabetes Res Care

Specialty Endocrinology

Date 2016 Aug 4

PMID 27486520

Citations 12

Authors

Alex L Barwick

John W Tessier

Xanne Janse de Jonge

James R Ivers

Vivienne H Chuter

Affiliations

Soon will be listed here.

Abstract

Objective: This study examined whether the presence of peripheral sensory neuropathy or cardiac autonomic deficits is associated with postocclusive reactive hyperemia (reflective of microvascular function) in the diabetic foot.

Research Design And Methods: 99 participants with type 2 diabetes were recruited into this cross-sectional study. The presence of peripheral sensory neuropathy was determined with standard clinical tests and cardiac autonomic function was assessed with heart rate variation testing. Postocclusive reactive hyperemia was measured with laser Doppler in the hallux. Multiple hierarchical regression was performed to examine relationships between neuropathy and the peak perfusion following occlusion and the time to reach this peak.

Results: Peripheral sensory neuropathy predicted 22% of the variance in time to peak following occlusion (p<0.05), being associated with a slower time to peak but was not associated with the magnitude of the peak. Heart rate variation was not associated with the postocclusive reactive hyperemia response.

Conclusions: This study found an association between the presence of peripheral sensory neuropathy in people with diabetes and altered microvascular reactivity in the lower limb.

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