Use of LDH and Autoimmune Side Effects to Predict Response to Ipilimumab Treatment

Overview

Journal Immunotherapy

Specialties Allergy & Immunology
Pharmacology

Date 2016 Aug 4

PMID 27485076

Citations 28

Authors

J Dick

N Lang

A Slynko

A Kopp-Schneider

C Schulz

A Dimitrakopoulou-Strauss

A H Enk

J C Hassel

Affiliations

Soon will be listed here.

Abstract

Background: Ipilimumab is a cytotoxic T-lymphocyte antigen-4 antibody that enhances T-cell activity and proliferation.

Methods: In a retrospective analysis of 86 patients the clinical benefits of ipilimumab treatment were correlated with laboratory and clinical data.

Results: A lactate dehydrogenase (LDH) value within the normal range before the start of therapy was significantly correlated with better OS (p ≤ 0.009). An increase in LDH level after two cycles was indicative of a poor outcome, and was significantly negatively correlated with treatment response and overall survival and progression-free survival. 42% of all patients suffered from autoimmune toxicity (CTCAE grades 2-4). The occurrence of autoimmune toxicity clearly correlated with clinical benefit.

Conclusion: Changes in LDH level and side effects correlate with response to therapy and survival.

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