The Myeloid Heat Shock Transcription Factor 1/β-catenin Axis Regulates NLR Family, Pyrin Domain-containing 3 Inflammasome Activation in Mouse Liver Ischemia/reperfusion Injury

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2016 Jul 31

PMID 27474884

Citations 59

Authors

Shi Yue

Jianjun Zhu

Ming Zhang

Changyong Li

Xingliang Zhou

Min Zhou

Michael Ke

Ronald W Busuttil

Qi-Long Ying

Jerzy W Kupiec-Weglinski

Qiang Xia

Bibo Ke

Affiliations

Soon will be listed here.

Abstract

Conclusion: The myeloid HSF1-β-catenin axis controlled NLRP3 activation by modulating the XBP1 signaling pathway. HSF1 activation promoted β-catenin, which, in turn, inhibited XBP1, leading to NLRP3 inactivation and reduced I/R-induced liver injury. These findings demonstrated that HSF1/β-catenin signaling is a novel regulator of innate immunity in liver inflammatory injury and implied the therapeutic potential for management of sterile liver inflammation in transplant recipients. (Hepatology 2016;64:1683-1698).

Citing Articles

Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury.

Qu X, Xu D, Yang T, Tian Y, King C, Wang X Redox Biol. 2024; 79():103455.

PMID: 39644526 PMC: 11667066. DOI: 10.1016/j.redox.2024.103455.

β-Catenin disruption decreases macrophage exosomal α-SNAP and impedes Treg differentiation in acute liver injury.

Zong R, Liu Y, Zhang M, Liu B, Zhang W, Hu H JCI Insight. 2024; 10(1.

PMID: 39560996 PMC: 11721303. DOI: 10.1172/jci.insight.182515.

Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-Sting pathway.

Xiong Y, Chen J, Liang W, Li K, Huang Y, Song J J Transl Med. 2024; 22(1):796.

PMID: 39198913 PMC: 11351313. DOI: 10.1186/s12967-024-05588-8.

Age-dependent heat shock hormesis to HSF-1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans.

Kovacs D, Biro J, Ahmed S, Kovacs M, Sigmond T, Hotzi B Aging Cell. 2024; 23(10):e14246.

PMID: 38895933 PMC: 11464127. DOI: 10.1111/acel.14246.

Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning.

Xiao F, Huang G, Yuan G, Li S, Wang Y, Tan Z Front Immunol. 2024; 15:1372441.

PMID: 38690269 PMC: 11058647. DOI: 10.3389/fimmu.2024.1372441.

References

Suzuki S, Rodriguez F, Cejalvo D . Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation. 1993; 55(6):1265-72. DOI: 10.1097/00007890-199306000-00011. View

Zhou R, Yazdi A, Menu P, Tschopp J . A role for mitochondria in NLRP3 inflammasome activation. Nature. 2010; 469(7329):221-5. DOI: 10.1038/nature09663. View

Li Q, Harraz M, Zhou W, Zhang L, Ding W, Zhang Y . Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Mol Cell Biol. 2005; 26(1):140-54. PMC: 1317618. DOI: 10.1128/MCB.26.1.140-154.2006. View

Kamo N, Ke B, Ghaffari A, Shen X, Busuttil R, Cheng G . ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology. 2013; 58(1):351-62. PMC: 3679353. DOI: 10.1002/hep.26320. View

Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel A, Johnson R, Nizet V . Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007; 178(12):7516-9. DOI: 10.4049/jimmunol.178.12.7516. View

Murapa P, Ward M, Gandhapudi S, Woodward J, DOrazio S . Heat shock factor 1 protects mice from rapid death during Listeria monocytogenes infection by regulating expression of tumor necrosis factor alpha during fever. Infect Immun. 2010; 79(1):177-84. PMC: 3019880. DOI: 10.1128/IAI.00742-09. View

Ke B, Shen X, Zhang Y, Ji H, Gao F, Yue S . KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013; 59(6):1200-7. PMC: 4524560. DOI: 10.1016/j.jhep.2013.07.016. View

Tanaka K, Namba T, Arai Y, Fujimoto M, Adachi H, Sobue G . Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem. 2007; 282(32):23240-52. DOI: 10.1074/jbc.M704081200. View

Idzko M, Ferrari D, Eltzschig H . Nucleotide signalling during inflammation. Nature. 2014; 509(7500):310-7. PMC: 4222675. DOI: 10.1038/nature13085. View

10.

Rao J, Yue S, Fu Y, Zhu J, Wang X, Busuttil R . ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant. 2014; 14(7):1552-61. PMC: 4074706. DOI: 10.1111/ajt.12711. View

11.

Neef D, Jaeger A, Thiele D . Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. Nat Rev Drug Discov. 2011; 10(12):930-44. PMC: 3518299. DOI: 10.1038/nrd3453. View

12.

Phillip West A, Brodsky I, Rahner C, Woo D, Erdjument-Bromage H, Tempst P . TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature. 2011; 472(7344):476-80. PMC: 3460538. DOI: 10.1038/nature09973. View

13.

Mariathasan S, Monack D . Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol. 2006; 7(1):31-40. DOI: 10.1038/nri1997. View

14.

Eltzschig H, Bratton D, Colgan S . Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov. 2014; 13(11):852-69. PMC: 4259899. DOI: 10.1038/nrd4422. View

15.

Kastner D, Aksentijevich I, Goldbach-Mansky R . Autoinflammatory disease reloaded: a clinical perspective. Cell. 2010; 140(6):784-90. PMC: 3541025. DOI: 10.1016/j.cell.2010.03.002. View

16.

Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H . Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007; 282(15):11221-9. PMC: 1850976. DOI: 10.1074/jbc.M611871200. View

17.

Kim H, Wu J, Ye S, Tai C, Zhou X, Yan H . Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun. 2013; 4:2403. PMC: 4183150. DOI: 10.1038/ncomms3403. View

18.

Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K . XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2002; 107(7):881-91. DOI: 10.1016/s0092-8674(01)00611-0. View

19.

Zhang L, Jiang H, Gao X, Zou Y, Liu M, Liang Y . Heat shock transcription factor-1 inhibits H2O2-induced apoptosis via down-regulation of reactive oxygen species in cardiac myocytes. Mol Cell Biochem. 2010; 347(1-2):21-8. DOI: 10.1007/s11010-010-0608-1. View

20.

Froh M, Konno A, Thurman R . Isolation of liver Kupffer cells. Curr Protoc Toxicol. 2012; Chapter 14:Unit14.4. DOI: 10.1002/0471140856.tx1404s14. View