Irritable Bowel Syndrome, the Microbiota and the Gut-brain Axis

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2016 Jul 30

PMID 27472486

Citations 78

Authors

Hans Raskov

Jakob Burcharth

Hans-Christian Pommergaard

Jacob Rosenberg

Affiliations

Soon will be listed here.

Abstract

Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.

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