Clinicopathological Features and Prognosis of Omental Gastrointestinal Stromal Tumor: Evaluation of a Pooled Case Series

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jul 30

PMID 27471066

Citations 2

Authors

Fan Feng

Yangzi Tian

Zhen Liu

Shushang Liu

Guanghui Xu

Man Guo

Xiao Lian

Daiming Fan

Hongwei Zhang

Affiliations

Soon will be listed here.

Abstract

Clinicopathological features and prognosis of omental GISTs are limited due to the extremely rare incidence. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of omental GISTs. Omental GISTs cases were obtained from our center and from case reports and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed. A total of 99 cases of omental GISTs were enrolled in the present study. Omental GISTs occurred predominantly in greater omentum (78/99, 78.8%). The majority of tumors exceeded 10 cm in diameter (67/98, 68.3%) and were high risk (88/96, 91.7%). Histological type was correlated with tumor location and mutational status. The five year DFS and DSS was 86.3% and 80.6%, respectively. Mitotic index was risk factor for prognosis of omental GISTs. Prognosis of omental GISTs was worse than that of gastric GISTs by Kaplan-Meier analysis. However, multivariate analysis showed that the prognosis was comparable between the two groups. The majority of omental GISTs were large and high risk. Mitotic index was risk factor for prognosis of omental GISTs. The prognosis was comparable between omental and gastric GISTs.

Citing Articles

Unusual location of gastrointestinal stromal tumor (GIST): A case report and literature review of greater omentum location.

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Extragastrointestinal stromal tumour of the lesser omentum: A case report and literature review.

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References

Kim J, Boo Y, Jung C, Park S, Kim S, Mok Y . Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis: a case report. World J Gastroenterol. 2007; 13(24):3392-5. PMC: 4172724. DOI: 10.3748/wjg.v13.i24.3392. View

Terada T . Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene. World J Gastroenterol. 2008; 14(47):7256-9. PMC: 2776887. DOI: 10.3748/wjg.14.7256. View

Agaimy A, Wang L, Eck M, Haller F, Chetty R . Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor α mutations. Ann Diagn Pathol. 2012; 17(2):187-91. DOI: 10.1016/j.anndiagpath.2012.10.005. View

Franzini C, Alessandri L, Piscioli I, Donato S, Faraci R, Morelli L . Extra-gastrointestinal stromal tumor of the greater omentum: report of a case and review of the literature. World J Surg Oncol. 2008; 6:25. PMC: 2267191. DOI: 10.1186/1477-7819-6-25. View

Divakaran J, Chander B . Primary extra-gastrointestinal stromal tumor of the omentum. J Cancer Res Ther. 2012; 8(3):433-5. DOI: 10.4103/0973-1482.103527. View

Yamamoto H, Kojima A, Nagata S, Tomita Y, Takahashi S, Oda Y . KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 cases. Am J Surg Pathol. 2011; 35(9):1287-95. DOI: 10.1097/PAS.0b013e3182206f15. View

Tarchouli M, Bounaim A, Essarghini M, Aitidir B, Lomdo M, Benmoussa M . Extra-Gastrointestinal Stromal Tumor of the Greater Omentum: Unusual Case Report. J Gastrointest Cancer. 2015; 47(4):489-493. DOI: 10.1007/s12029-015-9784-2. View

Yoshimura N, Ohara H, Miyabe K, Ban T, Sano H, Naitoh I . A case of gastrointestinal stromal tumor with spontaneous rupture in the greater omentum. Int Semin Surg Oncol. 2008; 5:19. PMC: 2515846. DOI: 10.1186/1477-7800-5-19. View

Joensuu H . Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 2008; 39(10):1411-9. DOI: 10.1016/j.humpath.2008.06.025. View

10.

Mouaqit O, Jahid A, Ifrine L, Omar El Malki H, Mohsine R, Mahassini N . Primary omental gastrointestinal stromal tumors. Clin Res Hepatol Gastroenterol. 2011; 35(8-9):590-3. DOI: 10.1016/j.clinre.2010.11.012. View

11.

Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen S, Brabec P . Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. 2011; 13(3):265-74. DOI: 10.1016/S1470-2045(11)70299-6. View

12.

Zhu J, Yang Z, Tang G, Wang Z . Extragastrointestinal stromal tumors: Computed tomography and magnetic resonance imaging findings. Oncol Lett. 2014; 9(1):201-208. PMC: 4246649. DOI: 10.3892/ol.2014.2705. View

13.

Liu H, Li W, Zhu S . Clinical images. Extragastrointestinal stromal tumor of lesser omentum mimicking a liver tumor. Am J Surg. 2008; 197(1):e7-8. DOI: 10.1016/j.amjsurg.2008.04.006. View

14.

Fukuda H, Suwa T, Kimura F, Sugiura T, Shinoda T, Kaneko K . Gastrointestinal stromal tumor of the lesser omentum: report of a case. Surg Today. 2001; 31(8):715-8. DOI: 10.1007/s005950170077. View

15.

Fagkrezos D, Touloumis Z, Giannila M, Penlidis C, Papaparaskeva K, Triantopoulou C . Extra-gastrointestinal stromal tumor of the omentum: a rare case report and review of the literature. Rare Tumors. 2012; 4(3):e44. PMC: 3475951. DOI: 10.4081/rt.2012.e44. View

16.

Amendolara M, Ramuscello S, Broggiato A, Andreotti A, Stevanato G, Bonfiglio M . Rare cases reports of gastrointestinal stromal tumour (GIST). G Chir. 2014; 35(5-6):129-33. PMC: 4321515. View

17.

Murayama Y, Yamamoto M, Iwasaki R, Miyazaki T, Saji Y, Doi Y . Greater omentum gastrointestinal stromal tumor with PDGFRA-mutation and hemoperitoneum. World J Gastrointest Oncol. 2012; 4(5):119-24. PMC: 3360106. DOI: 10.4251/wjgo.v4.i5.119. View

18.

Dedemadi G, Georgoulis G, Kontopanos D, Anagnostou E, Morphopoulos G, Emile J . Extragastrointestinal stromal tumors of the omentum: review apropos of a case with a novel gain-of-function KIT mutation. J Gastrointest Cancer. 2009; 40(3-4):73-8. DOI: 10.1007/s12029-009-9089-4. View

19.

Cai N, Morgenstern N, Wasserman P . A case of omental gastrointestinal stromal tumor and association with history of melanoma. Diagn Cytopathol. 2003; 28(6):342-4. DOI: 10.1002/dc.10292. View

20.

Nakaya I, Iwata Y, Abe T, Yokoyama H, Oda Y, Nomura G . Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma. Intern Med. 2004; 43(2):102-5. DOI: 10.2169/internalmedicine.43.102. View