Effects of Multidrug Resistant Tuberculosis Treatment on Patients' Health Related Quality of Life: Results from a Follow Up Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Jul 29

PMID 27467560

Citations 22

Authors

Nafees Ahmad

Arshad Javaid

Syed Azhar Syed Sulaiman

Anila Basit

Afsar Khan Afridi

Ammar Ali Saleh Jaber

Amer Hayat Khan

Affiliations

Soon will be listed here.

Abstract

Background: At present, within the management of multidrug resistant tuberculosis (MDR-TB) much attention is being paid to the traditional microbiological and clinical indicators. Evaluation of the impact of MDR-TB treatment on patients' Health Related Quality of Life (HRQoL) has remained a neglected area.

Objective: To evaluate the impact of MDR-TB treatment on patients HRQoL, and determine the predictors of variability in HRQoL along the course of treatment.

Methods: A prospective follow up study was conducted at the programmatic management unit for drug resistant TB of Lady Reading Hospital Peshawar. Culture confirmed eligible MDR-TB patients were asked to self complete SF-36v2 at the baseline visit, and subsequently after the completion of 12 months of treatment and at the end of treatment. A score of <47 norm-based scoring (NBS) points on component summary measures and health domain scales was considered indicative of function impairment. General linear model repeated measures ANOVA was used examine the change and predictors of change in physical component summary (PCS) and mental component summary (MCS) scores over the time.

Results: A total of 68 out of enrolled 81 eligible MDR-TB patients completed SF-36v2 questionnaire at the three time points. Patients' mean PCS scores at the three time points were, 38.2±4.7, 38.6±4.4 and 42.2±5.2 respectively, and mean MCS were 33.7±7.0, 35.5±6.9 and 40.0±6.9 respectively. Length of sickness prior to the diagnosis of MDR-TB was predictive of difference in PCS scores (F = 4.988, Df = 1, 66), whereas patients' gender (F = 5.638, Df = 1, 66) and length of sickness prior to the diagnosis of MDR-TB (F = 4.400, Df = 1, 66) were predictive of difference in MCS scores.

Conclusion: Despite the positive impact of MDR-TB treatment on patients' HRQoL, the scores on component summary measures suggested compromised physical and mental health even at the end of treatment. A large multicenter study is suggested to confirm the present findings.

Citing Articles

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References

Breslau N, Davis G, Andreski P, Peterson E, Schultz L . Sex differences in posttraumatic stress disorder. Arch Gen Psychiatry. 1997; 54(11):1044-8. DOI: 10.1001/archpsyc.1997.01830230082012. View

Williams K . Has the future of marriage arrived? A contemporary examination of gender, marriage, and psychological well-being. J Health Soc Behav. 2004; 44(4):470-87. PMC: 4018193. View

Sharma R, Yadav R, Sharma M, Saini V, Koushal V . Quality of life of multi drug resistant tuberculosis patients: a study of north India. Acta Med Iran. 2014; 52(6):448-53. View

Guo N, Marra F, Fitzgerald J, Elwood R, Marra C . Impact of adverse drug reaction and predictivity of quality of life status in tuberculosis. Eur Respir J. 2010; 36(1):206-8. DOI: 10.1183/09031936.00159409. View

Sherbourne C, Sturm R, Wells K . What outcomes matter to patients?. J Gen Intern Med. 1999; 14(6):357-63. PMC: 1496594. DOI: 10.1046/j.1525-1497.1999.00354.x. View

Dhuria M, Sharma N, Singh N, Jiloha R, Saha R, Ingle G . A study of the impact of tuberculosis on the quality of life and the effect after treatment with DOTS. Asia Pac J Public Health. 2009; 21(3):312-20. DOI: 10.1177/1010539509336242. View

Nasrullah M, Bhatti J . Gender inequalities and poor health outcomes in Pakistan: a need of priority for the national health research agenda. J Coll Physicians Surg Pak. 2012; 22(5):273-4. DOI: 05.2012/JCPSP.273274. View

Muniyandi M, Rajeswari R, Balasubramanian R, Nirupa C, Gopi P, Jaggarajamma K . Evaluation of post-treatment health-related quality of life (HRQoL) among tuberculosis patients. Int J Tuberc Lung Dis. 2007; 11(8):887-92. View

Ahmad N, Javaid A, Basit A, Afridi A, Khan M, Ahmad I . Management and treatment outcomes of MDR-TB: results from a setting with high rates of drug resistance. Int J Tuberc Lung Dis. 2015; 19(9):1109-14, i-ii. DOI: 10.5588/ijtld.15.0167. View

10.

Leidy N, Revicki D, Geneste B . Recommendations for evaluating the validity of quality of life claims for labeling and promotion. Value Health. 2006; 2(2):113-27. DOI: 10.1046/j.1524-4733.1999.02210.x. View

11.

Chavez Pachas A, Blank R, Smith Fawzi M, Bayona J, Becerra M, Mitnick C . Identifying early treatment failure on category I therapy for pulmonary tuberculosis in Lima Ciudad, Peru. Int J Tuberc Lung Dis. 2004; 8(1):52-8. View

12.

Furin J, Gegia M, Mitnick C, Rich M, Shin S, Becerra M . Eliminating the category II retreatment regimen from national tuberculosis programme guidelines: the Georgian experience. Bull World Health Organ. 2012; 90(1):63-6. PMC: 3260578. DOI: 10.2471/BLT.11.092320. View

13.

Thomas B, Shanmugam P, Malaisamy M, Ovung S, Suresh C, Subbaraman R . Psycho-Socio-Economic Issues Challenging Multidrug Resistant Tuberculosis Patients: A Systematic Review. PLoS One. 2016; 11(1):e0147397. PMC: 4726571. DOI: 10.1371/journal.pone.0147397. View

14.

Lam C, Tse E, Gandek B, Fong D . The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population. J Clin Epidemiol. 2005; 58(8):815-22. DOI: 10.1016/j.jclinepi.2004.12.008. View

15.

Rajeswari R, Muniyandi M, Balasubramanian R, Narayanan P . Perceptions of tuberculosis patients about their physical, mental and social well-being: a field report from south India. Soc Sci Med. 2005; 60(8):1845-53. DOI: 10.1016/j.socscimed.2004.08.024. View

16.

Weissman M, Bland R, Canino G, Faravelli C, Greenwald S, Hwu H . Cross-national epidemiology of major depression and bipolar disorder. JAMA. 1996; 276(4):293-9. View

17.

Avong Y, Isaakidis P, Hinderaker S, Van den Bergh R, Ali E, Obembe B . Doing no harm? Adverse events in a nation-wide cohort of patients with multidrug-resistant tuberculosis in Nigeria. PLoS One. 2015; 10(3):e0120161. PMC: 4364363. DOI: 10.1371/journal.pone.0120161. View

18.

Weiss E, Longhurst J, Mazure C . Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates. Am J Psychiatry. 1999; 156(6):816-28. DOI: 10.1176/ajp.156.6.816. View

19.

Vega P, SWEETLAND A, Acha J, Castillo H, Guerra D, Smith Fawzi M . Psychiatric issues in the management of patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2004; 8(6):749-59. View

20.

Kittikraisak W, Kingkaew P, Teerawattananon Y, Yothasamut J, Natesuwan S, Manosuthi W . Health related quality of life among patients with tuberculosis and HIV in Thailand. PLoS One. 2012; 7(1):e29775. PMC: 3256183. DOI: 10.1371/journal.pone.0029775. View