Epigenetic Roles in the Malignant Transformation of Gastric Mucosal Cells

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2016 Jul 29

PMID 27464701

Citations 8

Authors

Jun Tie

Xiangyuan Zhang

Daiming Fan

Affiliations

Soon will be listed here.

Abstract

Gastric carcinogenesis occurs when gastric epithelial cells transition through the initial, immortal, premalignant, and malignant stages of transformation. Epigenetic regulations contribute to this multistep process. Due to the critical role of epigenetic modifications , these changes are highly likely to be of clinical use in the future as new biomarkers and therapeutic targets for the early detection and treatment of cancers. Here, we summarize the recent findings on how epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, regulate gastric carcinogenesis, and we discuss potential new strategies for the diagnosis and treatments of gastric cancer. The strategies may be helpful in the further understanding of epigenetic regulation in human diseases.

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