ABO Blood Type is Associated with Ovarian Reserve in Chinese Women with Subfertility

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Jul 28

PMID 27462770

Citations 3

Authors

Liangshan Mu

Wumin Jin

Haiyan Yang

Xia Chen

Jiexue Pan

Jia Lin

Peiyu Wang

Xuefeng Huang

Affiliations

Soon will be listed here.

Abstract

Ovarian reserve reflects both the quantity and quality of oocytes available for procreation, and is affected by many known and unknown factors. ABO blood type is related to a number of infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve. Here, we explored the relationship between ABO blood type and ovarian reserve in Chinese women with subfertility. Day-3 serum follicle-stimulating hormone (FSH) levels and blood type were examined in 14,875 women who underwent IVF or ICSI treatment. Blood type proportions in the patient population were as follows: 30.98% type A, 24.54% type B, 7.57% type AB, and 36.91% type O. A higher percentage of women with diminished ovarian reserve (DOR) were blood type O, while a lower percentage had the B antigen (B and AB). Multiple logistic regression analysis revealed that blood type O was associated with a greater risk of DOR than blood type B and B antigen-positive types. By contrast, the B antigen (B and AB) was associated with a lower incidence of DOR than blood type O. These results suggest that blood type O is a risk factor for DOR while the B antigen (blood type B or AB) is a protective factor for ovarian reserve in Chinese women with subfertility. Further studies are needed to confirm this effect and identify the underlying mechanisms.

Citing Articles

Association of ABO blood groups with ovarian reserve: a retrospective cohort study in Chinese Han women younger than 40 years with infertility.

Sun X, Sun C, Meng M, Liu L J Ovarian Res. 2022; 15(1):132.

PMID: 36539903 PMC: 9769009. DOI: 10.1186/s13048-022-01075-0.

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses.

Zhao J, Yao Z, Hao J, Xu B, Wang Y, Li Y Reprod Biol Endocrinol. 2021; 19(1):20.

PMID: 33549121 PMC: 7866457. DOI: 10.1186/s12958-020-00685-x.

ABO blood group and ovarian reserve: a meta-analysis and systematic review.

Deng J, Jia M, Cheng X, Yan Z, Fan D, Tian X Oncotarget. 2017; 8(15):25628-25636.

PMID: 28445964 PMC: 5421956. DOI: 10.18632/oncotarget.15759.

References

Cordts E, Santos M, Bianco B, Barbosa C, Christofolini D . Are FSHR polymorphisms risk factors to premature ovarian insufficiency?. Gynecol Endocrinol. 2015; 31(8):663-6. DOI: 10.3109/09513590.2015.1032933. View

Dharmesh S, Baenziger J . Estrogen modulates expression of the glycosyltransferases that synthesize sulfated oligosaccharides on lutropin. Proc Natl Acad Sci U S A. 1993; 90(23):11127-31. PMC: 47935. DOI: 10.1073/pnas.90.23.11127. View

Fusco F, Paciolla M, Chen E, Li X, Genesio R, Conti A . Genetic and molecular analysis of a new unbalanced X;18 rearrangement: localization of the diminished ovarian reserve disease locus in the distal Xq POF1 region. Hum Reprod. 2011; 26(11):3186-96. DOI: 10.1093/humrep/der266. View

Greenseid K, Jindal S, Zapantis A, Nihsen M, Hurwitz J, Pal L . Declining ovarian reserve adversely influences granulosa cell viability. Fertil Steril. 2008; 91(6):2611-5. DOI: 10.1016/j.fertnstert.2008.03.065. View

Johnson N, Bagrie E, Coomarasamy A, Bhattacharya S, Shelling A, Jessop S . Ovarian reserve tests for predicting fertility outcomes for assisted reproductive technology: the International Systematic Collaboration of Ovarian Reserve Evaluation protocol for a systematic review of ovarian reserve test accuracy. BJOG. 2006; 113(12):1472-80. DOI: 10.1111/j.1471-0528.2006.01068.x. View

Palcic M, Seto N, Hindsgaul O . Natural and recombinant A and B gene encoded glycosyltransferases. Transfus Med. 2001; 11(4):315-23. DOI: 10.1046/j.1365-3148.2001.00314.x. View

Clark A . The role of haplotypes in candidate gene studies. Genet Epidemiol. 2004; 27(4):321-33. DOI: 10.1002/gepi.20025. View

Randolph Jr J, Sowers M, Bondarenko I, Harlow S, Luborsky J, Little R . Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age. J Clin Endocrinol Metab. 2004; 89(4):1555-61. DOI: 10.1210/jc.2003-031183. View

Sun W, Stegmann B, Henne M, Catherino W, Segars J . A new approach to ovarian reserve testing. Fertil Steril. 2008; 90(6):2196-202. PMC: 2655110. DOI: 10.1016/j.fertnstert.2007.10.080. View

10.

Levi A, Raynault M, Bergh P, Drews M, Miller B, Scott Jr R . Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril. 2001; 76(4):666-9. DOI: 10.1016/s0015-0282(01)02017-9. View

11.

Hurwitz J, Jindal S, Greenseid K, Berger D, Brooks A, Santoro N . Reproductive aging is associated with altered gene expression in human luteinized granulosa cells. Reprod Sci. 2009; 17(1):56-67. DOI: 10.1177/1933719109348028. View

12.

Lourenco D, Brauner R, Lin L, De Perdigo A, Weryha G, Muresan M . Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med. 2009; 360(12):1200-10. PMC: 2778147. DOI: 10.1056/NEJMoa0806228. View

13.

Nejat E, Jindal S, Berger D, Buyuk E, Lalioti M, Pal L . Implications of blood type for ovarian reserve. Hum Reprod. 2011; 26(9):2513-7. DOI: 10.1093/humrep/der199. View

14.

Thum M, Kalu E, Abdalla H . Elevated basal FSH and embryo quality: lessons from extended culture embryos: raised FSH and blastocyst quality. J Assist Reprod Genet. 2009; 26(6):313-8. PMC: 2729851. DOI: 10.1007/s10815-009-9313-y. View

15.

Peprah E . Understanding decreased fertility in women carriers of the FMR1 premutation: a possible mechanism for Fragile X-Associated Primary Ovarian Insufficiency (FXPOI). Reprod Health. 2014; 11:67. PMC: 4141264. DOI: 10.1186/1742-4755-11-67. View

16.

Schaid D . Evaluating associations of haplotypes with traits. Genet Epidemiol. 2004; 27(4):348-64. DOI: 10.1002/gepi.20037. View

17.

Lin S, Li R, Chi H, Huang S, Zhang H, Zheng X . Effect of ABO blood type on ovarian reserve in Chinese women. Fertil Steril. 2014; 102(6):1729-32.e2. DOI: 10.1016/j.fertnstert.2014.09.008. View

18.

Broer S, Broekmans F, Laven J, Fauser B . Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications. Hum Reprod Update. 2014; 20(5):688-701. DOI: 10.1093/humupd/dmu020. View

19.

Sengul O, Dilbaz B, Yerebasmaz N, Dede S, Altinbas S, Erkaya S . Only female age, and not blood type, is associated with ovarian reserve. Int J Fertil Steril. 2014; 8(2):143-6. PMC: 4107687. View

20.

Wood M, Rajkovic A . Genomic markers of ovarian reserve. Semin Reprod Med. 2013; 31(6):399-415. PMC: 4043392. DOI: 10.1055/s-0033-1356476. View