Nutritional Concerns in Pediatric Inflammatory Bowel Disease

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2016 Jul 28

PMID 27462352

Citations 1

Authors

Yong Joo Kim

Affiliations

Soon will be listed here.

Abstract

The pathophysiology and fundamental etiologic mechanism of inflammatory bowel disease (IBD) is not well understood even though therapeutic regimens and drugs are rapidly evolutionary. IBD has complicated connections with genetic, immunologic, gut microbial, environmental, and nutritional factors. It is not clearly well known to the physicians how to feed, what nutrients are more helpful, and what food to be avoided. This review discusses the issues of growth and important nutritional concerns in the management of IBD in childhood.

Citing Articles

Inflammatory Bowel Disease in Children: Current Diagnosis and Treatment Strategies.

Bhalla A, Shahi A, Maity M, Safa F, Srividya V, Clementina R Cureus. 2025; 17(2):e78462.

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The Management Approach to the Adolescent IBD Patient: Health Maintenance and Medication Considerations.

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References

Kremer J, Galivan J, Streckfuss A, Kamen B . Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates. Arthritis Rheum. 1986; 29(7):832-5. DOI: 10.1002/art.1780290703. View

Vortia E, Kay M, Wyllie R . The role of growth hormone and insulin-like growth factor-1 in Crohn's disease: implications for therapeutic use of human growth hormone in pediatric patients. Curr Opin Pediatr. 2011; 23(5):545-51. DOI: 10.1097/MOP.0b013e32834a7810. View

Vance D . Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis. Curr Opin Lipidol. 2008; 19(3):229-34. DOI: 10.1097/MOL.0b013e3282fee935. View

Seidman E, LeLeiko N, Ament M, Berman W, Caplan D, Evans J . Nutritional issues in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1991; 12(4):424-38. DOI: 10.1097/00005176-199105000-00004. View

De Ley M, De Vos R, Hommes D, Stokkers P . Fish oil for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2007; (4):CD005986. DOI: 10.1002/14651858.CD005986.pub2. View

Sirotnak F, Tolner B . Carrier-mediated membrane transport of folates in mammalian cells. Annu Rev Nutr. 1999; 19:91-122. DOI: 10.1146/annurev.nutr.19.1.91. View

Santucci N, Alkhouri R, Baker R, Baker S . Vitamin and zinc status pretreatment and posttreatment in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2014; 59(4):455-7. DOI: 10.1097/MPG.0000000000000477. View

Lashner B, Provencher K, Seidner D, Knesebeck A, Brzezinski A . The effect of folic acid supplementation on the risk for cancer or dysplasia in ulcerative colitis. Gastroenterology. 1997; 112(1):29-32. DOI: 10.1016/s0016-5085(97)70215-4. View

Basson A . Vitamin D and Crohn's disease in the adult patient: a review. JPEN J Parenter Enteral Nutr. 2013; 38(4):438-58. DOI: 10.1177/0148607113506013. View

10.

Schoon E, Muller M, Vermeer C, Schurgers L, Brummer R, Stockbrugger R . Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease?. Gut. 2001; 48(4):473-7. PMC: 1728221. DOI: 10.1136/gut.48.4.473. View

11.

Nowak J, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D . Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease. Sci Rep. 2014; 4:4768. PMC: 3998013. DOI: 10.1038/srep04768. View

12.

Bjerrum J, Nielsen O, Hao F, Tang H, Nicholson J, Wang Y . Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology. J Proteome Res. 2009; 9(2):954-62. DOI: 10.1021/pr9008223. View

13.

Wine E, Reif S, Leshinsky-Silver E, Weiss B, Shaoul R, Shamir R . Pediatric Crohn's disease and growth retardation: the role of genotype, phenotype, and disease severity. Pediatrics. 2004; 114(5):1281-6. DOI: 10.1542/peds.2004-0417. View

14.

Okada Y, Tsuzuki Y, Sato H, Narimatsu K, Hokari R, Kurihara C . Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. Clin Exp Immunol. 2013; 174(3):459-71. PMC: 3826312. DOI: 10.1111/cei.12200. View

15.

Malik S, Ahmed S, Wilson M, Shah N, Loganathan S, Naik S . The effects of anti-TNF-α treatment with adalimumab on growth in children with Crohn's disease (CD). J Crohns Colitis. 2012; 6(3):337-44. DOI: 10.1016/j.crohns.2011.09.004. View

16.

Griffiths A, Nguyen P, Smith C, MacMillan J, Sherman P . Growth and clinical course of children with Crohn's disease. Gut. 1993; 34(7):939-43. PMC: 1374230. DOI: 10.1136/gut.34.7.939. View

17.

Martensson K, Chrysis D, Savendahl L . Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones. J Bone Miner Res. 2004; 19(11):1805-12. DOI: 10.1359/JBMR.040805. View

18.

Mallon D, Suskind D . Nutrition in pediatric inflammatory bowel disease. Nutr Clin Pract. 2010; 25(4):335-9. DOI: 10.1177/0884533610373773. View

19.

Monk J, Hou T, Turk H, Weeks B, Wu C, McMurray D . Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS One. 2012; 7(11):e49739. PMC: 3500317. DOI: 10.1371/journal.pone.0049739. View

20.

Werner T, Wagner S, Martinez I, Walter J, Chang J, Clavel T . Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis. Gut. 2010; 60(3):325-33. DOI: 10.1136/gut.2010.216929. View