Association Between Celiac Disease and Chronic Hepatitis C

Overview

Journal Gastroenterol Hepatol Bed Bench

Specialty Gastroenterology

Date 2016 Jul 27

PMID 27458507

Citations 4

Authors

Giovanni Casella

Davide Vigano

Carlo Romano Settanni

Olivia Morelli

Vincenzo Villanacci

Vittorio Baldini

Gabrio Bassotti

Affiliations

Soon will be listed here.

Abstract

Celiac disease is characterized by a gluten-induced damage of the small bowel in sensitive individuals that may cause malabsorption. Non-intestinal inflammatory diseases may trigger immunologic gluten intolerance in susceptible people and the HCV virus may be considered as a suitable candidate. Interferon therapy could precipitate symptom onset in subjects with silent celiac disease. In fact, symptoms such as diarrhea, anemia, and weight loss may occur during interferon therapy and are associated with serological positivity of anti-tranglutaminase antibodies. To date, considering the available literature data, it is very difficult to support a firm association between HCV chronic hepatitis and celiac disease. Thus, such a serological screening in HCV patients before starting interferon therapy should not be recommended. However, serology for celiac disease must be considered in patients who develop diarrhea and/or weight loss during such therapy.

Citing Articles

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Viruses and celiac disease: what do we know ?.

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Coeliac disease: beyond genetic susceptibility and gluten. A narrative review.

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Celiac disease and hepatitis C relationships in transcriptional regulatory networks.

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