Higher Gene Expression of CYP1A2, 2B1 and 2D2 in the Brain of Female Compared with Male Rats

Overview

Journal Pharmazie

Specialties Pharmacology
Pharmacy

Date 2016 Jul 27

PMID 27455552

Citations 7

Authors

K Nagai

S Fukuno

H Suzuki

H Konishi

Affiliations

Soon will be listed here.

Abstract

Cytochrome P450 (CYP) in the brain plays an essential role in the local metabolism of various compounds, including clinically used drugs, toxins, and endogenous substances. In the present study, we compared the expression profiles of mRNAs for several CYP subtypes in the brain between male and female rats. The expression of CYP1A2, CYP2B1, and CYP2D2 in females was significantly higher than that in males. On the other hand, the expression level of the other CYP subtypes examined in the male brain was similar to that in the female brain. These results strongly suggest that marked gender differences exist in the expression profiles of some CYP subtypes in rat brain.

Citing Articles

Human CYP2D6 varies across the estrous cycle in brains of transgenic mice altering drug response.

Miksys S, McDonald C, Baghai Wadji F, Gonzalez F, Tyndale R Prog Neuropsychopharmacol Biol Psychiatry. 2024; 135:111108.

PMID: 39069248 PMC: 11402587. DOI: 10.1016/j.pnpbp.2024.111108.

Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner.

Walker K, Rhodes S, Liberman D, Gore A, Bell M Neurotoxicology. 2024; 104:95-115.

PMID: 39038526 PMC: 11548868. DOI: 10.1016/j.neuro.2024.07.009.

Gene×environment interactions in autism spectrum disorders.

Keil-Stietz K, Lein P Curr Top Dev Biol. 2023; 152:221-284.

PMID: 36707213 PMC: 10496028. DOI: 10.1016/bs.ctdb.2022.11.001.

Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier.

Ikeda-Murakami K, Tani N, Ikeda T, Aoki Y, Ishikawa T Int J Mol Sci. 2022; 23(3).

PMID: 35163784 PMC: 8836437. DOI: 10.3390/ijms23031862.

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.

Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z Signal Transduct Target Ther. 2021; 6(1):94.

PMID: 33637672 PMC: 7910446. DOI: 10.1038/s41392-020-00443-w.