Impact of Diabetes-Specific Nutritional Formulas Versus Oatmeal on Postprandial Glucose, Insulin, GLP-1 and Postprandial Lipidemia

Overview

Journal Nutrients

Date 2016 Jul 26

PMID 27455318

Citations 18

Authors

Adham Mottalib

Barakatun-Nisak Mohd-Yusof

Mohamed Shehabeldin

David M Pober

Joanna Mitri

Osama Hamdy

Affiliations

Soon will be listed here.

Abstract

Diabetes-specific nutritional formulas (DSNFs) are frequently used as part of medical nutrition therapy for patients with diabetes. This study aims to evaluate postprandial (PP) effects of 2 DSNFs; Glucerna (GL) and Ultra Glucose Control (UGC) versus oatmeal (OM) on glucose, insulin, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and triglycerides (TG). After an overnight fast, 22 overweight/obese patients with type 2 diabetes were given 200 kcal of each of the three meals on three separate days in random order. Blood samples were collected at baseline and at 30, 60, 90, 120, 180 and 240 min. Glucose area under the curve (AUC0-240) after GL and UGC was lower than OM (p < 0.001 for both). Insulin positive AUC0-120 after UGC was higher than after OM (p = 0.02). GLP-1 AUC0-120 and AUC0-240 after GL and UGC was higher than after OM (p < 0.001 for both). FFA and TG levels were not different between meals. Intake of DSNFs improves PP glucose for 4 h in comparison to oatmeal of similar caloric level. This is achieved by either direct stimulation of insulin secretion or indirectly by stimulating GLP-1 secretion. The difference between their effects is probably related to their unique blends of amino acids, carbohydrates and fat.

Citing Articles

Postprandial glycemic response to a high-protein diabetes-specific nutritional shake compared to isocaloric instant oatmeal in people with type 2 diabetes: a randomized, controlled, crossover trial.

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Diabetes-Specific Complete Smoothie Formulas Improve Postprandial Glycemic Response in Obese Type 2 Diabetic Individuals: A Randomized Crossover Trial.

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Effects of a novel rice-based diabetes-specific formula on postprandial glucose and gastrointestinal hormones: a double-blinded multi-arm randomized crossover trial.

Chaiyakul S, Ketkham N, Chaichana C, Khumkhana N, Deekum W, Wongshaya P Front Endocrinol (Lausanne). 2023; 14:1141497.

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Commentary: Is there a role for diabetes-specific nutrition formulas as meal replacements in type 2 diabetes?.

Glenn A, Liu S Front Endocrinol (Lausanne). 2023; 13:1094954.

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Is There a Role for Diabetes-Specific Nutrition Formulas as Meal Replacements in Type 2 Diabetes?.

Noronha J, Mechanick J Front Endocrinol (Lausanne). 2022; 13:874968.

PMID: 35573987 PMC: 9099205. DOI: 10.3389/fendo.2022.874968.

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