Asthma-Chronic Obstructive Pulmonary Diseases Overlap Syndrome Increases the Risk of Incident Tuberculosis: A National Cohort Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Jul 23

PMID 27448309

Citations 8

Authors

Jun-Jun Yeh

Yu-Chiao Wang

Chia-Hung Kao

Affiliations

Soon will be listed here.

Abstract

Purpose: The association between asthma-chronic obstructive pulmonary diseases (COPD) overlap syndrome (ACOS) and tuberculosis (TB) has yet to be studied.

Methods: The newly diagnosed TB patients (age > 20 y) treated from January 2000 to December 2008 were included (ACOS cohort, n = 10 751; non-ACOS cohort, n = 42 966). The non-ACOS cohort involved patients with confirmed absence of ACOS. We calculated incidence rate ratios (IRRs) for TB in the ACOS and non-ACOS cohorts by using poisson regression analysis. Cox proportional hazards regression models were used to determine the adjusted HR (aHR) for TB in the ACOS cohort compared with the non-ACOS cohort.

Results: The aHR for TB was 2.41 (95% confidence interval [CI], 2.19-2.66) in the ACOS cohort. The TB risk was significantly higher in the ACOS cohort than in the non-ACOS cohort when stratified by age, sex, comorbidities, and atopy. Within the ACOS cohort, the aHR was higher among patients receiving SABAs+SAMAs, LABAs+LAMAs, and ICSs (aHR [95% CI]: 3.06 [2.75-3.41], 3.68 [2.93-4.61], and 2.79 [1.25-6.22], respectively; all P < .05). Furthermore, patients with more than 15 outpatient visits and hospitalizations per year demonstrated the highest aHR (8.09; 95% CI, 6.85-9.56).

Conclusions: ACOS cohort potentially develop incident TB, regardless of the age,sex, comorbidities and atopy; even without receiving the inhalers.This risk is higher, especially in the ACOS cohort have a high frequency of medical services or receiving the inhalers such as SABAs+SAMAs, LABAs+LAMAs and ICSs.

Citing Articles

Associations among chronic obstructive pulmonary disease with asthma, pneumonia, and corticosteroid use in the general population.

Yeh J, Lin C, Kao C PLoS One. 2020; 15(2):e0229484.

PMID: 32092112 PMC: 7039502. DOI: 10.1371/journal.pone.0229484.

Inhaled Corticosteroids And Risk Of Tuberculosis In Patients With Obstructive Lung Diseases: A Systematic Review And Meta-Analysis Of Non-randomized Studies.

Castellana G, Castellana M, Castellana C, Castellana G, Resta E, Carone M Int J Chron Obstruct Pulmon Dis. 2019; 14:2219-2227.

PMID: 31576118 PMC: 6769028. DOI: 10.2147/COPD.S209273.

Statin for Tuberculosis and Pneumonia in Patients with Asthma⁻Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study.

Yeh J, Lin C, Hsu C, Shae Z, Kao C J Clin Med. 2018; 7(11).

PMID: 30355982 PMC: 6262333. DOI: 10.3390/jcm7110381.

Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study.

Yeh J, Wei Y, Lin C, Hsu W Oncotarget. 2018; 9(15):12418-12431.

PMID: 29552322 PMC: 5844758. DOI: 10.18632/oncotarget.23811.

Predictors of asthma-chronic obstructive pulmonary disease overlap syndrome in patients with chronic obstructive pulmonary disease from a tertiary care center in India.

Ayub I, Arshad A, Sekar P, Manimaran N, Thangaswamy D, Chockalingam C Lung India. 2018; 35(2):137-142.

PMID: 29487249 PMC: 5846263. DOI: 10.4103/lungindia.lungindia_198_17.

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