Basolateral Amygdala Nucleus Responses to Appetitive Conditioned Stimuli Correlate with Variations in Conditioned Behaviour

Overview

Journal Nat Commun

Specialty Biology

Date 2016 Jul 23

PMID 27447354

Citations 11

Authors

Seung-Chan Lee

Alon Amir

Drew B Headley

Darrell Haufler

Denis Pare

Affiliations

Soon will be listed here.

Abstract

In the lateral amygdala (LA), training-induced increases in neuronal responsiveness to conditioned stimuli (CSs) reflect potentiated sensory responses that drive conditioned behaviours (CRs) via LA's targets. The basolateral nucleus of the amygdala (BL) receives LA inputs and projects to various subcortical sites that can drive aversive and appetitive CRs. Consistent with this, BL neurons also develop increased responses to CSs that predict rewarding or aversive outcomes. This increased BL activity is thought to reflect the potentiated sensory responses of LA neurons. Here we contrast the CS-related activity of BL neurons when rats produced the expected CR or not, to show that cells activated by appetitive CSs mainly encode behavioural output, not CS identity. The strong dependence of BL activity on behaviour irrespective of CS identity suggests that feedforward connectivity from LA to BL can be overridden by other BL inputs.

Citing Articles

Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States.

Ottenheimer D, Vitale K, Ambroggi F, Janak P, Saunders B J Neurosci. 2024; 44(46).

PMID: 39353730 PMC: 11561866. DOI: 10.1523/JNEUROSCI.0013-24.2024.

Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex.

Ottenheimer D, Vitale K, Ambroggi F, Janak P, Saunders B bioRxiv. 2024; .

PMID: 38260546 PMC: 10802313. DOI: 10.1101/2023.12.31.573789.

State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.

Lutas A, Kucukdereli H, Alturkistani O, Carty C, Sugden A, Fernando K Nat Neurosci. 2019; 22(11):1820-1833.

PMID: 31611706 PMC: 6858554. DOI: 10.1038/s41593-019-0506-0.

WHEN SCIENTIFIC PARADIGMS LEAD TO TUNNEL VISION: LESSONS FROM THE STUDY OF FEAR.

Pare D, Quirk G NPJ Sci Learn. 2018; 2.

PMID: 30294453 PMC: 6171770.

Multi-dimensional Coding by Basolateral Amygdala Neurons.

Kyriazi P, Headley D, Pare D Neuron. 2018; 99(6):1315-1328.e5.

PMID: 30146300 PMC: 6342465. DOI: 10.1016/j.neuron.2018.07.036.

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