Biomaterials for Pluripotent Stem Cell Engineering: From Fate Determination to Vascularization

Overview

Journal J Mater Chem B

Publisher Royal Society of Chemistry

Specialty Biomedical Engineering

Date 2016 Jul 23

PMID 27446588

Citations 8

Authors

Nailah M Seale

Shyni Varghese

Affiliations

Soon will be listed here.

Abstract

Recent advancements in material science and engineering may hold the key to overcoming reproducibility and scalability limitations currently hindering the clinical translation of stem cell therapies. Biomaterial assisted differentiation commitment of stem cells and modulation of their function could have significant impact in stem cell-centred regenerative medicine approaches and next gen technological platforms. Synthetic biomaterials are of particular interest as they provide a consistent, chemically defined, and tunable way of mimicking the physical and chemical properties of the natural tissue or cell environment. Combining emerging biomaterial and biofabrication advancements may finally give researchers the tools to modulate spatiotemporal complexity and engineer more hierarchically complex, physiologically relevant tissue mimics. In this review we highlight recent research advancements in biomaterial assisted pluripotent stem cell (PSC) expansion and three dimensional (3D) tissue formation strategies. Furthermore, since vascularization is a major challenge affecting the function of engineered tissues, we discuss recent developments in vascularization strategies and assess their ability to produce perfusable and functional vasculature that can be integrated with the host tissue.

Citing Articles

Biomaterials as a Vital Frontier for Stem Cell-Based Tissue Regeneration.

Nugud A, Alghfeli L, Elmasry M, El-Serafi I, El-Serafi A Front Cell Dev Biol. 2022; 10:713934.

PMID: 35399531 PMC: 8987776. DOI: 10.3389/fcell.2022.713934.

Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture system.

Ngo T, Rossbach B, Sebastien I, Neubauer J, Kurtz A, Hariharan K Cell Prolif. 2022; 55(3):e13190.

PMID: 35102634 PMC: 8891564. DOI: 10.1111/cpr.13190.

In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.

Zeng Y, Shih Y, Baht G, Varghese S Adv Mater. 2019; 32(8):e1906022.

PMID: 31833120 PMC: 7042087. DOI: 10.1002/adma.201906022.

[Local injection of angiopoietin 2 promotes angiogenesis in tissue engineered bone and repair of bone defect with autophagy induction ].

Yin J, Wang B, Zhu C, Sun C, Liu X Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018; 32(9):1150-1156.

PMID: 30129346 PMC: 8413973. DOI: 10.7507/1002-1892.201804105.

Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.

Seale N, Ramaswamy S, Shih Y, Verma I, Varghese S Transplantation. 2018; 102(9):e373-e381.

PMID: 29916986 PMC: 6102079. DOI: 10.1097/TP.0000000000002330.

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