Lithocholate in Liver Tissue with Obstructive Jaundice

Overview

Journal Gastroenterol Jpn

Specialty Gastroenterology

Date 1989 Apr 1

PMID 2744331

Citations 1

Authors

J Yanagisawa

M Nagai

Y Hirano

T Fujii

F Nakayama

Affiliations

Soon will be listed here.

Abstract

The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922-929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hepatic dysfunction in obstructive jaundice is minimal, if any.

Citing Articles

Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.

Trottier J, Bialek A, Caron P, Straka R, Milkiewicz P, Barbier O PLoS One. 2011; 6(7):e22094.

PMID: 21760958 PMC: 3132779. DOI: 10.1371/journal.pone.0022094.

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