Performance of CareHPV for Detecting High-grade Cervical Intraepithelial Neoplasia Among Women Living with HIV-1 in Burkina Faso and South Africa: HARP Study

Overview

Journal Br J Cancer

Specialty Oncology

Date 2016 Jul 20

PMID 27434037

Citations 22

Authors

Michel Segondy

Helen Kelly

Mahlape P Magooa

Florencia Djigma

Jean Ngou

Clare Gilham

Tanvier Omar

Olga Goumbri-Lompo

Pamela Michelow

Sylviane Doutre

Omar Clavero

Admire Chikandiwa

Bernard Sawadogo

Marie-Noelle Didelot

Valerie Costes

Nicolas Meda

Sinead Delany-Moretlwe

Philippe Mayaud

Affiliations

Soon will be listed here.

Abstract

Background: The careHPV assay is a test for high-risk (HR) human papillomaviruses (HPV) detection designed to be affordable in resource-poor settings. We evaluated the performance of careHPV screening among 1052 women living with HIV/AIDS included in the HARP (HPV in Africa Research Partnership) study in Burkina Faso (BF) and South Africa (SA).

Methods: Cervical samples were tested for HR-HPV by the careHPV and the INNO-LiPA HPV genotyping Extra assays. All women had Pap smear testing, visual inspection with acetic acid/Lugol's iodine (VIA/VILI) and colposcopy. Cervical biopsies were obtained for participants who were HR-HPV DNA positive by careHPV or who had abnormalities detected on cytology, VIA/VILI or colposcopy.

Results: Overall, 45.1% of women had a positive careHPV test (46.5% in BF, 43.8% in SA). The careHPV positivity rate increased with the grade of cytological lesions. Sensitivity and specificity of careHPV for the diagnosis of CIN2+ (n=60, both countries combined) were 93.3% (95% confidence interval (CI): 83.8-98.2) and 57.9% (95% CI: 54.5-61.2), respectively. Specificity increased with CD4 count. careHPV had a similar clinical sensitivity but higher specificity than the INNO-LiPA assay for detection of CIN2+.

Conclusions: Our results suggest that careHPV testing is a reliable tool for cervical cancer screening in HIV-1-infected women in sub-Saharan Africa.

Citing Articles

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Clifford G, Baussano I, Heideman D, Tshering S, Choden T, Lazzarato F Cancer Med. 2023; 12(10):11828-11837.

PMID: 36999740 PMC: 10619475. DOI: 10.1002/cam4.5851.

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