Intrinsic (Genetic) Aerobic Fitness Impacts Susceptibility for Metabolic Disease

Overview

Journal Exerc Sport Sci Rev

Specialty Orthopedics

Date 2016 Jul 20

PMID 27433978

Citations 9

Authors

John P Thyfault

E Matthew Morris

Affiliations

Soon will be listed here.

Citing Articles

Reduced Liver Mitochondrial Energy Metabolism Impairs Food Intake Regulation Following Gastric Preloads and Fasting.

Ponte M, Prom J, Newcomb M, Jordan A, Comfort L, Hu J bioRxiv. 2024; .

PMID: 39554188 PMC: 11565831. DOI: 10.1101/2024.10.24.620086.

Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.

Kugler B, Maurer A, Fu X, Franczak E, Ernst N, Schwartze K bioRxiv. 2024; .

PMID: 39484384 PMC: 11526936. DOI: 10.1101/2024.10.21.619494.

Divergence in aerobic capacity and energy expenditure influence metabolic tissue mitochondrial protein synthesis rates in aged rats.

Franczak E, Maurer A, Drummond V, Kugler B, Wells E, Wenger M Geroscience. 2023; 46(2):2207-2222.

PMID: 37880490 PMC: 10828174. DOI: 10.1007/s11357-023-00985-1.

Divergence in aerobic capacity influences hepatic and systemic metabolic adaptations to bile acid sequestrant and short-term high-fat/sucrose feeding in rats.

Kugler B, Cao X, Wenger M, Franczak E, McCoin C, Von Schulze A Am J Physiol Regul Integr Comp Physiol. 2023; 325(6):R712-R724.

PMID: 37811712 PMC: 11178297. DOI: 10.1152/ajpregu.00133.2023.

Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice.

Lee M, Hsu Y, Sung H, Wen Y, Wei L, Huang C Nutrients. 2022; 14(18).

PMID: 36145123 PMC: 9502809. DOI: 10.3390/nu14183746.

References

Bouchard C, Blair S, Katzmarzyk P . Less Sitting, More Physical Activity, or Higher Fitness?. Mayo Clin Proc. 2015; 90(11):1533-40. DOI: 10.1016/j.mayocp.2015.08.005. View

Baber U, Boffetta P . Improving fitness to achieve health: shifting the focus from theory to practice. J Am Coll Cardiol. 2015; 65(19):2101-3. DOI: 10.1016/j.jacc.2015.03.542. View

Ricci M, Levin B . Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2003; 285(3):R610-8. DOI: 10.1152/ajpregu.00235.2003. View

Booth F, Roberts C, Laye M . Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2013; 2(2):1143-211. PMC: 4241367. DOI: 10.1002/cphy.c110025. View

Noland R, Thyfault J, Henes S, Whitfield B, Woodlief T, Evans J . Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2007; 293(1):E31-41. DOI: 10.1152/ajpendo.00500.2006. View

Toedebusch R, Ruegsegger G, Braselton J, Heese A, Hofheins J, Childs T . AMPK agonist AICAR delays the initial decline in lifetime-apex V̇o2 peak, while voluntary wheel running fails to delay its initial decline in female rats. Physiol Genomics. 2015; 48(2):101-15. DOI: 10.1152/physiolgenomics.00078.2015. View

Rector R, Thyfault J, Morris R, Laye M, Borengasser S, Booth F . Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol. 2008; 294(3):G619-26. DOI: 10.1152/ajpgi.00428.2007. View

Rottensteiner M, Leskinen T, Niskanen E, Aaltonen S, Mutikainen S, Wikgren J . Physical activity, fitness, glucose homeostasis, and brain morphology in twins. Med Sci Sports Exerc. 2014; 47(3):509-18. DOI: 10.1249/MSS.0000000000000437. View

Fernandez-Marcos P, Auwerx J . Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr. 2011; 93(4):884S-90. PMC: 3057551. DOI: 10.3945/ajcn.110.001917. View

10.

Park Y, Rector R, Thyfault J, Zidon T, Padilla J, Welly R . Effects of ovariectomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity. Am J Physiol Endocrinol Metab. 2015; 310(3):E190-9. PMC: 4888527. DOI: 10.1152/ajpendo.00434.2015. View

11.

Yoon J, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J . Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001; 413(6852):131-8. DOI: 10.1038/35093050. View

12.

Bernal-Mizrachi C, Semenkovich C . Fast predators or fast food, the fit still survive. Nat Med. 2006; 12(1):46-7. DOI: 10.1038/nm0106-46. View

13.

Naples S, Borengasser S, Rector R, Uptergrove G, Morris E, Mikus C . Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab. 2010; 35(2):151-62. PMC: 2894534. DOI: 10.1139/H09-139. View

14.

Koch L, Kemi O, Qi N, Leng S, Bijma P, Gilligan L . Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res. 2011; 109(10):1162-72. PMC: 3236084. DOI: 10.1161/CIRCRESAHA.111.253807. View

15.

Blair S, Kohl 3rd H, Paffenbarger Jr R, Clark D, COOPER K, Gibbons L . Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA. 1989; 262(17):2395-401. DOI: 10.1001/jama.262.17.2395. View

16.

Stephenson E, Lessard S, Rivas D, Watt M, Yaspelkis 3rd B, Koch L . Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab. 2013; 305(3):E429-38. PMC: 4073983. DOI: 10.1152/ajpendo.00544.2012. View

17.

Morris E, Jackman M, Johnson G, Liu T, Lopez J, Kearney M . Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab. 2014; 307(4):E355-64. PMC: 4137118. DOI: 10.1152/ajpendo.00093.2014. View

18.

Thyfault J, Rector R, Uptergrove G, Borengasser S, Morris E, Wei Y . Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. J Physiol. 2009; 587(Pt 8):1805-16. PMC: 2683966. DOI: 10.1113/jphysiol.2009.169060. View

19.

Rector R, Thyfault J, Uptergrove G, Morris E, Naples S, Borengasser S . Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010; 52(5):727-36. PMC: 3070177. DOI: 10.1016/j.jhep.2009.11.030. View

20.

Kokkinos P, Myers J, Kokkinos J, Pittaras A, Narayan P, Manolis A . Exercise capacity and mortality in black and white men. Circulation. 2008; 117(5):614-22. DOI: 10.1161/CIRCULATIONAHA.107.734764. View