The Role of Magnesium in the Pathogenesis and Treatment of Glaucoma

Overview

Journal Int Sch Res Notices

Specialty Biology

Date 2016 Jul 20

PMID 27433524

Citations 9

Authors

Feyzahan Ekici

Safak Korkmaz

Emine Esra Karaca

Sabahattin Sul

Hasan Ali Tufan

Bahri Aydin

Ergin Dilekoz

Affiliations

Soon will be listed here.

Abstract

Glaucoma is characterized by chronic optic neuropathy resulting in progressive vision loss. Not only is glaucoma considered as a condition of elevated intraocular pressure (IOP), but also other risk factors may play a role in the pathogenesis of glaucomatous optic nerve damage. Vascular dysregulation in ocular blood flow and oxidative stress are currently suggested as important risk factors for glaucomatous retinal ganglion cell loss. New treatment modalities that improve ocular blood flow and reduce oxidative stress have been investigated in many studies. Magnesium (Mg) is thought to be one of the molecules that has a treatment potential in glaucoma. Mg has been shown to improve blood flow by modifying endothelial function via endothelin-1 (ET-1) and endothelial nitric oxide (NO) pathways. Mg also exhibits neuroprotective role by blocking N-methyl-D-aspartate (NMDA) receptor-related calcium influx and by inhibiting the release of glutamate, and hence protects the cell against oxidative stress and apoptosis. Both improvement in ocular blood flow and prevention of ganglion cell loss would make magnesium a good candidate for glaucoma management. Further studies on the effect of Mg may open a new therapeutic era in glaucoma.

Citing Articles

Magnesium and Its Role in Primary Open Angle Glaucoma; A Novel Therapeutic?.

Elghobashy M, Lamont H, Morelli-Batters A, Masood I, Hill L Front Ophthalmol (Lausanne). 2024; 2:897128.

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Association between dietary calcium, potassium, and magnesium consumption and glaucoma.

Zhang Y, Zhao Z, Ma Q, Li K, Zhao X, Jia Z PLoS One. 2023; 18(10):e0292883.

PMID: 37851631 PMC: 10584168. DOI: 10.1371/journal.pone.0292883.

'Magnesium'-the master cation-as a drug-possibilities and evidences.

Mathew A, Panonnummal R Biometals. 2021; 34(5):955-986.

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Influence of Trace Elements on Neurodegenerative Diseases of The Eye-The Glaucoma Model.

Kaminska A, Romano G, Rejdak R, Zweifel S, Fiedorowicz M, Rejdak M Int J Mol Sci. 2021; 22(9).

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Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos).

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PMID: 33818520 PMC: 8354133. DOI: 10.4103/1673-5374.310691.

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