Clinicopathological Features of Ganglioneuroma Originating From the Adrenal Glands

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2016 Jul 20

PMID 27431319

Citations 14

Authors

Joon-Hyop Lee

Young Jun Chai

Tae-Hyung Kim

June Young Choi

Kyu Eun Lee

Hyun-Young Kim

Yoo-Seok Yoon

Hyeon Hoe Kim

Affiliations

Soon will be listed here.

Abstract

Background: Ganglioneuromas are benign tumors that rarely develop from adrenal glands. In this study, we present our clinical experience of patients with adrenal ganglioneuroma (AGN).

Methods: Demographic, diagnostic, surgical, and pathologic findings of patients who were adrenalectomized as a result of AGN were retrospectively reviewed from the database of a tertiary referral hospital.

Results: Among 1784 patients who underwent an adrenalectomy between 2002 and 2015, 35 (1.9 %; 14 males, 21 females) were diagnosed with AGN. Mean age was 33.4 ± 18.7 years (0-84). Twenty-nine (82.9 %) were asymptomatic, four (11.4 %) complained of abdominal discomfort, and two (5.7 %) had abdominal distension. Preoperative computed tomography (CT) reported AGN in 22 (62.9 %) cases. Precontrast Hounsfield units, increased postcontrast phase attenuation, and well-defined borders were characteristic CT features of AGN. Mean tumor size was 6.3 ± 3.3 cm (range, 1.5-16.0). No recurrence occurred during a median follow-up period of 19 months (range, 1-120).

Conclusion: AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.

Citing Articles

Adrenal Ganglioneuroma With Radiology-Pathology Correlation.

Rueda-de-Eusebio A, de la Torre Serrano M, Victoria Artalejo A, Mendez R Cureus. 2024; 16(9):e69584.

PMID: 39421099 PMC: 11484185. DOI: 10.7759/cureus.69584.

Combined exploratory laparotomy, transpsoas, and thoracic approach to resection of a giant spinal ganglioneuroma: illustrative case.

Deng H, Habib A, Andrews E, Zhang X, McCarthy D, Wei Z J Neurosurg Case Lessons. 2023; 5(2).

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Diagnosis and surgical treatment of adrenal ganglioneuroma: a retrospective cohort study of 51 patients in a single center.

Lei K, Wang X, Liu Y, Sun T, Xie W, Ma M Am J Transl Res. 2022; 14(10):7528-7534.

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Adrenal Ganglioneuroma: A Case Report.

Aynaou H, Salhi H, El Ouahabi H Cureus. 2022; 14(8):e27634.

PMID: 36072207 PMC: 9438294. DOI: 10.7759/cureus.27634.

Adrenal ganglioneuroma: Prognostic factors (Review).

Sandru F, Dumitrascu M, Petca A, Carsote M, Petca R, Oproiu A Exp Ther Med. 2021; 22(5):1338.

PMID: 34630692 PMC: 8495554. DOI: 10.3892/etm.2021.10773.

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