Radioprotective Effect of Grape Seed Proanthocyanidins In Vitro and In Vivo

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2016 Jul 19

PMID 27429710

Citations 10

Authors

Yijuan Huang

Hainan Zhao

Kun Cao

Ding Sun

Yanyong Yang

Cong Liu

Jianguo Cui

Ying Cheng

Bailong Li

Jianming Cai

Fu Gao

Affiliations

Soon will be listed here.

Abstract

We have demonstrated that grape seed proanthocyanidins (GSPs) could effectively scavenge hydroxyl radical (•OH) in a dose-dependent manner. Since most of the ionizing radiation- (IR-) induced injuries were caused by •OH, this study was to investigate whether GSPs would mitigate IR-induced injuries in vitro and in vivo. We demonstrated that GSPs could significantly reduce IR-induced DNA strand breaks (DSBs) and apoptosis of human lymphocyte AHH-1 cells. This study also showed that GSPs could protect white blood cells (WBC) from IR-induced injuries, speed up the weight of mice back, and decrease plasma malondialdehyde (MDA), thus improving the survival rates of mice after ionizing radiation. It is suggested that GSPs have a potential as an effective and safe radioprotective agent.

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