Severe Type 2 Diabetes Induces Reversible Modifications of Endothelial Progenitor Cells Which Are Ameliorate by Glycemic Control

Overview

Journal Int J Stem Cells

Date 2016 Jul 19

PMID 27426095

Citations 11

Authors

Maria Rosaria De Pascale

Giuseppe Bruzzese

Ettore Crimi

Vincenzo Grimaldi

Antonio Liguori

Sergio Brongo

Michelangela Barbieri

Antonietta Picascia

Concetta Schiano

Linda Sommese

Nicola Ferrara

Giuseppe Paolisso

Claudio Napoli

Affiliations

Soon will be listed here.

Abstract

Background: Circulating endothelial progenitors cells (EPCs) play a critical role in neovascularization and endothelial repair. There is a growing evidence that hyperglycemia related to Diabetes Mellitus (DM) decreases EPC number and function so promoting vascular complications.

Aim Of The Study: This study investigated whether an intensive glycemic control regimen in Type 2 DM can increase the number of EPCs and restores their function.

Methods: Sixty-two patients with Type 2 DM were studied. Patients were tested at baseline and after 3 months of an intensive regimen of glycemic control. The Type 2 DM group was compared to control group of subjects without diabetes. Patients with Type 2 DM (mean age 58.2±5.4 years, 25.6% women, disease duration of 15.4±6.3 years) had a baseline HgA1c of 8.7±0.5% and lower EPC levels (CD34+/KDR+) in comparison to healthy controls (p<0.01).

Results: The intensive glycemic control regimen (HgA1c decreased to 6.2±0.3%) was coupled with a significant increase of EPC levels (mean of 18%, p<0.04 vs. baseline) and number of EPCs CFUs (p<0.05 vs. baseline).

Conclusion: This study confirms that number and bioactivity of EPCs are reduced in patients with Type 2 DM and, most importantly, that the intensive glycemic control in Type 2 DM promotes EPC improvement both in their number and in bioactivity.

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