Gastrodin Reversed the Traumatic Stress-induced Depressed-like Symptoms in Rats

Overview

Journal J Nat Med

Publisher Springer

Date 2016 Jul 16

PMID 27417451

Citations 11

Authors

Bombi Lee

Bongjun Sur

Mijung Yeom

Insop Shim

Hyejung Lee

Dae-Hyun Hahm

Affiliations

Soon will be listed here.

Abstract

Exposure to severe stress can lead to the development of neuropsychiatric disorders such as depression and post-traumatic stress disorder (PTSD) in at-risk individuals. Gastrodin (GAS), a primary constituent of an Oriental herbal medicine, has been shown to effectively treat various mood disorders. Thus, the present study aimed to determine whether GAS would ameliorate stress-associated depression-like behaviors in a rat model of single prolonged stress (SPS)-induced PTSD. Following the SPS procedure, rats received intraperitoneal administration of GAS (20, 50, or 100 mg/kg) once daily for 2 weeks. Subsequently, the rats performed the forced swimming test, and norepinephrine (NE) levels in the hippocampus were measured. Daily GAS (100 mg/kg) significantly reversed depression-like behaviors and restored SPS-induced increases in hippocampal NE concentrations as well as tyrosine hydroxylase expression in the locus coeruleus. Furthermore, the administration of GAS attenuated SPS-induced decreases in the hypothalamic expression of neuropeptide Y and the hippocampal mRNA expression of brain-derived neurotrophic factor. These findings indicate that GAS possesses antidepressant effects in the PTSD and may be an effective herbal preparation for the treatment of PTSD.

Citing Articles

Gastrodin, a Promising Natural Small Molecule for the Treatment of Central Nervous System Disorders, and Its Recent Progress in Synthesis, Pharmacology and Pharmacokinetics.

Dai Y, Ban W, Yang Z Int J Mol Sci. 2024; 25(17).

PMID: 39273485 PMC: 11394983. DOI: 10.3390/ijms25179540.

Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway.

Wang S, Yu L, Guo H, Zuo W, Guo Y, Liu H Mol Neurobiol. 2024; 62(1):366-385.

PMID: 38856794 DOI: 10.1007/s12035-024-04267-5.

Gastrodin: a comprehensive pharmacological review.

Wang Y, Bai M, Wang X, Peng Z, Cai C, Xi J Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(6):3781-3802.

PMID: 38165423 DOI: 10.1007/s00210-023-02920-9.

Review on pharmacological effects of gastrodin.

Xiao G, Tang R, Yang N, Chen Y Arch Pharm Res. 2023; 46(9-10):744-770.

PMID: 37749449 DOI: 10.1007/s12272-023-01463-0.

Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets.

Kozlakidis Z, Shi P, Abarbanel G, Klein C, Sfera A BioTech (Basel). 2023; 12(2).

PMID: 37218755 PMC: 10204439. DOI: 10.3390/biotech12020038.

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