Risk and Surveillance of Cancers in Primary Biliary Tract Disease

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2016 Jul 15

PMID 27413366

Citations 8

Authors

Valery Hrad

Yoftahe Abebe

Syed Haris Ali

Jared Velgersdyk

Mohammed Al Hallak

Mohamad Imam

Affiliations

Soon will be listed here.

Abstract

Primary biliary diseases have been associated in several studies with various malignancies. Understanding the risk and optimizing surveillance strategy of these malignancies in this specific subset of patients are an important facet of clinical care. For instance, primary sclerosing cholangitis is associated with an increased risk for cholangiocarcinoma (which is very challenging to diagnose) and when IBD is present for colorectal cancer. On the other hand, primary biliary cirrhosis patients with cirrhosis or not responding to 12 months of ursodeoxycholic acid therapy are at increased risk of hepatocellular carcinoma. In this review we will discuss in detail the risks and optimal surveillance strategies for patients with primary biliary diseases.

Citing Articles

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Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort.

Alsaleh M, Leftley Z, Barbera T, Koomson L, Zabron A, Crossey M J Clin Exp Hepatol. 2020; 10(1):17-29.

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Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review.

Song J, Li Y, Bowlus C, Yang G, Leung P, Gershwin M Clin Rev Allergy Immunol. 2019; 58(1):134-149.

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