Risk of Epilepsy in Stroke Patients Receiving Acupuncture Treatment: a Nationwide Retrospective Matched-cohort Study

Overview

Journal BMJ Open

Specialty General Medicine

Date 2016 Jul 15

PMID 27412100

Citations 11

Authors

Shu-Wen Weng

Chien-Chang Liao

Chun-Chieh Yeh

Ta-Liang Chen

Hsin-Long Lane

Jaung-Geng Lin

Chun-Chuan Shih

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the risk of epilepsy in stroke patients receiving and not receiving acupuncture treatment.

Design: Retrospective cohort study.

Setting: This study was based on Taiwan's National Health Insurance Research Database that included information on stroke patients hospitalised between 1 January 2000 and 31 December 2004.

Participants: We identified 42 040 patients hospitalised with newly diagnosed stroke who were aged 20 years and above.

Primary And Secondary Outcome Measures: We compared incident epilepsy during the follow-up period until the end of 2009 in stroke patients who were and were not receiving acupuncture. The adjusted HRs and 95% CIs of epilepsy associated with acupuncture were calculated using multivariate Cox proportional hazard regression.

Results: Stroke patients who received acupuncture treatment (9.8 per 1000 person-years) experienced a reduced incidence of epilepsy compared to those who did not receive acupuncture treatment (11.5 per 1000 person-years), with an HR of 0.74 (95% CI 0.68 to 0.80) after adjustment for sociodemographic factors and coexisting medical conditions. Acupuncture treatment was associated with a decreased risk of epilepsy, particularly among stroke patients aged 20-69 years. The log-rank test probability curve indicated that stroke patients receiving acupuncture treatment had a reduced probability of epilepsy compared with individuals who did not receive acupuncture treatment during the follow-up period (p<0.0001).

Conclusions: Stroke patients who received acupuncture treatment had a reduced risk of epilepsy compared with those not receiving acupuncture treatment. However, the protective effects associated with acupuncture treatment require further validation in prospective cohort studies.

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