Is Lipoprotein (a) Protective of Dementia?

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 2016 Jul 15

PMID 27412033

Citations 12

Authors

Setor K Kunutsor

Hassan Khan

Kristiina Nyyssonen

Jari A Laukkanen

Affiliations

Soon will be listed here.

Abstract

Lipoprotein(a) [Lp(a)]-an established risk factor for vascular disease, has been suggested to be associated with risk of dementia, however no prospective evidence exists to support this finding. We aimed to assess the association of Lp(a) with dementia risk. Lp(a) concentration was assessed at baseline in a prospective cohort of 2532 men aged 42-61 years. During a median follow-up of 24.9 years, 228 new cases of dementia were recorded. Lp(a) was approximately log-linearly associated with dementia risk. In age-adjusted analysis, the hazard ratio for dementia in a comparison of extreme quartiles of Lp(a) levels was 0.68 (95 % CI: 0.47-0.99), which persisted after adjustment for several physical measures, history of coronary heart disease, smoking status, history of diabetes, serum lipids, alcohol consumption, and socio-economic status 0.68 (0.46-0.99). Lp(a) is protective of future dementia risk in a middle-aged male Caucasian population. Further research is needed replicate these findings.

Citing Articles

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Associations of Lipoprotein(a) Level with Cerebral Small Vessel Disease in Patients with Alzheimer's Disease.

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Lipoprotein(a) and risk of cognitive impairment in Black and White Americans: the Reasons for Geographic and Racial Differences in Stroke cohort.

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Exploring the possible causal effects of cardiac blood biomarkers in dementia and cognitive performance: a Mendelian randomization study.

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Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases.

Pan Y, Cai X, Jing J, Wang S, Meng X, Mei L Stroke Vasc Neurol. 2022; .

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