Article: Presynaptic nicotinic cholinoreceptors modulate velocity of the action potential propagation along the motor nerve endings at a high-frequency synaptic activity

Experiments on frog neuromuscular junctions have demonstrated that asynchrony of the acetylcholine quantal release forming the multi-quantal evoked response at high-frequency synaptic activity is caused, in particular, by a decrease in velocity of the action potential propagation along the non-myelinated nerve endings, which is mediated by activation of the α7 and α4β4 nicotinic cholinoreceptors.

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Presynaptic Acetylcholine Receptors Modulate the Time Course of Action Potential-Evoked Acetylcholine Quanta Secretion at Neuromuscular Junctions.

Bukharaeva E, Skorinkin A, Samigullin D, Petrov A Biomedicines. 2022; 10(8).

PMID: 35892671 PMC: 9332499. DOI: 10.3390/biomedicines10081771.

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Presynaptic Nicotinic Cholinoreceptors Modulate Velocity of the Action Potential Propagation Along the Motor Nerve Endings at a High-frequency Synaptic Activity