High Osteoporosis Risk Among East Africans Linked to Lactase Persistence Genotype

Overview

Journal Bonekey Rep

Date 2016 Jul 14

PMID 27408710

Citations 2

Authors

Constance B Hilliard

Affiliations

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Abstract

This ecological correlation study explores the marked differential in osteoporosis susceptibility between East and West Africans. African tsetse belt populations are lactase non-persistent (lactose intolerant) and possess none of the genetic polymorphisms carried by lactase persistent (lactose tolerant) ethnic populations. What appears paradoxical, however, is the fact that Niger-Kordofanian (NK) West African ethnicities are also at minimal risk of osteoporosis. Although East Africans share a genetic affinity with NK West Africans, they display susceptibility rates of the bone disorder closer to those found in Europe. Similar to Europeans, they also carry alleles conferring the lactase persistence genetic traits. Hip fracture rates of African populations are juxtaposed with a global model to determine whether it is the unique ecology of the tsetse-infested zone or other variables that may be at work. This project uses MINITAB 17 software for regression analyses. The research data are found on AJOL (African Journals Online), PUBMED and JSTOR (Scholarly Journal Archive). Data showing the risk of osteoporosis to be 80 times higher among East Africans with higher levels of lactase persistence than lactase non-persistence West Africans are compared with global statistics. Hip fracture rates in 40 countries exhibit a high Pearson's correlation of r=0.851, with P-value=0.000 in relation to dairy consumption. Lower correlations are seen for hip fracture incidence vis-à-vis lactase persistence, per capita income and animal protein consumption. Ethnic populations who lack lactase persistence single-nucleotide polymorphisms may be at low risk of developing osteoporosis.

Citing Articles

Advances in Low-Lactose/Lactose-Free Dairy Products and Their Production.

Li A, Zheng J, Han X, Yang S, Cheng S, Zhao J Foods. 2023; 12(13).

PMID: 37444291 PMC: 10340681. DOI: 10.3390/foods12132553.

Comment on 'Dairy, calcium, vitamin D, and ovarian cancer risk in African-American women'.

Hilliard C Br J Cancer. 2018; 119(2):258-259.

PMID: 29961758 PMC: 6048103. DOI: 10.1038/s41416-018-0166-y.

References

Dhanwal D, Dennison E, Harvey N, Cooper C . Epidemiology of hip fracture: Worldwide geographic variation. Indian J Orthop. 2011; 45(1):15-22. PMC: 3004072. DOI: 10.4103/0019-5413.73656. View

Mattar R, Monteiro M, Villares C, Santos A, Silva J, Carrilho F . Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups. Nutr J. 2009; 8:46. PMC: 2761420. DOI: 10.1186/1475-2891-8-46. View

Pollock N, Hamilton B . Osteoporotic fracture in an elite male Kenyan athlete. Br J Sports Med. 2007; 42(12):1000-1. DOI: 10.1136/bjsm.2007.039818. View

Kanis J, Oden A, McCloskey E, Johansson H, Wahl D, Cooper C . A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int. 2012; 23(9):2239-56. PMC: 3421108. DOI: 10.1007/s00198-012-1964-3. View

Hassan H, Underhill P, Cavalli-Sforza L, Ibrahim M . Y-chromosome variation among Sudanese: restricted gene flow, concordance with language, geography, and history. Am J Phys Anthropol. 2008; 137(3):316-23. DOI: 10.1002/ajpa.20876. View

Oyoo G, Kariuki J . Osteoporosis--from hormonal replacement therapy to bisphosphonates and beyond: a review. East Afr Med J. 2008; 84(11):534-45. DOI: 10.4314/eamj.v84i11.9573. View

Yoshida Y, Sasaki G, Goto S, Yanagiya S, Takashina K . Studies on the etiology of milk intolerance in Japanese adults. Gastroenterol Jpn. 1975; 10(1):29-34. DOI: 10.1007/BF02775921. View

Redmond J, Jarjou L, Zhou B, Prentice A, Schoenmakers I . Ethnic differences in calcium, phosphate and bone metabolism. Proc Nutr Soc. 2014; 73(2):340-51. PMC: 3981475. DOI: 10.1017/S0029665114000068. View

Cavalli-Sforza L, Strata A, Barone A, Cucurachi L . Primary adult lactose malabsorption in Italy: regional differences in prevalence and relationship to lactose intolerance and milk consumption. Am J Clin Nutr. 1987; 45(4):748-54. DOI: 10.1093/ajcn/45.4.748. View

10.

Fujiwara N, Marti B, Gutzwiller F . Hip fracture mortality and morbidity in Switzerland and Japan: a cross-cultural comparison. Soz Praventivmed. 1993; 38(1):8-14. DOI: 10.1007/BF01321155. View

11.

Xu L, Sun H, Zhang X, Wang J, Sun D, Chen F . The -22018A allele matches the lactase persistence phenotype in northern Chinese populations. Scand J Gastroenterol. 2009; 45(2):168-74. DOI: 10.3109/00365520903414176. View

12.

Kokkonen J, Tikkanen S, Savilahti E . Residual intestinal disease after milk allergy in infancy. J Pediatr Gastroenterol Nutr. 2001; 32(2):156-61. DOI: 10.1097/00005176-200102000-00012. View

13.

Nagy D, Bogacsi-Szabo E, Varkonyi A, Csanyi B, Czibula A, Bede O . Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians. Eur J Clin Nutr. 2009; 63(7):909-12. DOI: 10.1038/ejcn.2008.74. View

14.

Nordin B . International patterns of osteoporosis. Clin Orthop Relat Res. 1966; 45:17-30. View

15.

Abelow B, Holford T, Insogna K . Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int. 1992; 50(1):14-8. DOI: 10.1007/BF00297291. View

16.

Swallow D . Genetics of lactase persistence and lactose intolerance. Annu Rev Genet. 2003; 37:197-219. DOI: 10.1146/annurev.genet.37.110801.143820. View

17.

Campbell M, Tishkoff S . African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet. 2008; 9:403-33. PMC: 2953791. DOI: 10.1146/annurev.genom.9.081307.164258. View

18.

Wang Y, Yan Y, Xu J, Du R, Flatz S, Kuhnau W . Prevalence of primary adult lactose malabsorption in three populations of northern China. Hum Genet. 1984; 67(1):103-6. DOI: 10.1007/BF00270566. View

19.

Campbell M, Tishkoff S . The evolution of human genetic and phenotypic variation in Africa. Curr Biol. 2010; 20(4):R166-73. PMC: 2945812. DOI: 10.1016/j.cub.2009.11.050. View

20.

Tuzun S, Eskiyurt N, Akarirmak U, Saridogan M, Senocak M, Johansson H . Incidence of hip fracture and prevalence of osteoporosis in Turkey: the FRACTURK study. Osteoporos Int. 2011; 23(3):949-55. DOI: 10.1007/s00198-011-1655-5. View