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Role of Prophylactic Antibiotics in Laparoscopic Cholecystectomy

Overview
Journal Med J Armed Forces India
Specialty General Medicine
Date 2016 Jul 14
PMID 27408307
Citations 9
Authors
A Gaur
A K Pujahari
Affiliations
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Abstract

Background: Antibiotic prophylaxis is routinely administered in laparoscopic cholecystetomy but its role is debatable.

Methods: From January 2004 to August 2008, 417 patients were randomized into 208 in antibiotic group (AG) and 209 in non antibiotic group (NAG). AG received one dose each of injection ciprofloxacin (200 mg) and metronidazole (500mg) preoperatively. NAG was given only intravenous fluids. Besides routine care, all underwent abdominal sonography and liver function tests at least once during the 30 postoperative days.

Result: Age, sex and co-morbidity distribution were similar in both the groups. One patient who was on weekly 5mg methotraxate (NAG) had erythema around umbilical port. Other three having umbilical discharge recovered without antibiotics. Nine patients had subhepatic collection (5 AG and 4 NAG). One from NAG underwent re-laparoscopy and drainage. Ten patients had fever. Two from AG had basal lung collapse and were given antibiotics.

Conclusion: Antibiotic prophylaxis is not needed for laparoscopic cholecystectomy.

Citing Articles

Prophylactic antibiotics in laparoscopic cholecystectomy: Reducing postoperative infection risk-A meta-analysis and trial sequential analysis.

Wang S, Gao Q, Qi X, Hong L, Huang H Heliyon. 2025; 11(4):e41982.

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The effect of antibiotic prophylaxis on the incidence of surgical site infection after laparoscopic appendectomy for chronic appendicitis.

Dai L, Jin X, Xie H, He T, Cheng H, Zhu Y Heliyon. 2023; 9(5):e15578.

PMID: 37153397 PMC: 10160511. DOI: 10.1016/j.heliyon.2023.e15578.

Current practice of antibiotic prophylaxis in elective laparoscopic cholecystectomy among surgeons of the Armed Forces Medical Services of India.

Kumar A, Kaistha S Med J Armed Forces India. 2022; 78(2):192-197.

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Reduction of risk of infection during elective laparoscopic cholecystectomy using prophylactic antibiotics: a systematic review and meta-analysis.

Yang J, Gong S, Lu T, Tian H, Jing W, Liu Y Surg Endosc. 2021; 35(12):6397-6412.

PMID: 34370122 DOI: 10.1007/s00464-021-08658-w.

Role of prophylactic antibiotics in elective laparoscopic cholecystectomy: A systematic review and meta-analysis.

Kim S, Yu H, Yang J, Ahn S, Hwang H Ann Hepatobiliary Pancreat Surg. 2018; 22(3):231-247.

PMID: 30215045 PMC: 6125276. DOI: 10.14701/ahbps.2018.22.3.231.

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