Renal Transplantation - Calcutta Experience

Overview

Journal Med J Armed Forces India

Specialty General Medicine

Date 2016 Jul 14

PMID 27407381

Authors

P P Varma

Tapan Sinha

D Batura

R Malik

Rsv Kumar

G S Chopra

H S Gill

Affiliations

Soon will be listed here.

Abstract

31 renal transplant procedures have been performed at this centre. Renal donors were father in 4, mother in 4, brother in 12, sister in 4, brother-in-law in 1 and wives in 6 cases. Median age of recipients and donors was 35.2 years (20-55) and 38.3 years (24-60) respectively. After a mean follow up of 15.7 months (2-40), graft survival was 96.7% and patient survival 90-3%. Three patients (9.6%) required surgical re-exploration, one each for, peri-graft haematoma, arterial kink and graft artery thrombosis. 6 patients (19.3%) required anti rejection therapy with resultant complete normalisation of graft functions. Medical complications noted were post transplant diabetes mellitus in 6 (19.3%), azathihoprine induced bone marrow suppression in 1(3.2%), tuberculosis in 2 (6.4%), post transplant erythrocytosis in 2 (6.4%) and recurrent urinary tract infection (UTI) in one (3.2%) patients. 3 patients (9.6%) died with functioning graft, one due to lung infection and the other due to haemorrahagic pancreatitis and third due to infective endocarditis.

References

Dunn T, Asolati M, Holman D, Raofi V, Jovanovic B, Pollak R . Long-term outcome of a prospective trial of steroid withdrawal after kidney transplantation. Surgery. 1999; 125(2):155-9. View

Hariharan S, Johnson C, Bresnahan B, Taranto S, McIntosh M, Stablein D . Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med. 2000; 342(9):605-12. DOI: 10.1056/NEJM200003023420901. View

Sakhuja V, Jha V, Varma P, Joshi K, Chugh K . The high incidence of tuberculosis among renal transplant recipients in India. Transplantation. 1996; 61(2):211-5. DOI: 10.1097/00007890-199601270-00008. View

Macdougall I . The role of ACE inhibitors and angiotensin II receptor blockers in the response to epoetin. Nephrol Dial Transplant. 1999; 14(8):1836-41. DOI: 10.1093/ndt/14.8.1836. View

Dodhia N, Rodby R, Jensik S, Korbet S . Renal transplant arterial thrombosis: association with cyclosporine. Am J Kidney Dis. 1991; 17(5):532-6. DOI: 10.1016/s0272-6386(12)80494-x. View

Sakhuja V, Varma P, Kathuria P, Jha V, Chugh K . Bone tuberculosis: an unusual case of mycobacterial infection in a renal allograft recipient. Nephrol Dial Transplant. 1993; 8(9):868-70. View

Denton M, Magee C, Sayegh M . Immunosuppressive strategies in transplantation. Lancet. 1999; 353(9158):1083-91. DOI: 10.1016/S0140-6736(98)07493-5. View

Ghosh A, Verma P, Jha V, Gupta K, Sakhuja V, Chugh K . Disseminated tuberculosis in a renal transplant recipient presenting as a non-healing skin ulcer. A case report. Int J Artif Organs. 1993; 16(3):132-4. View

Ahsan N, Hricik D, Matas A, Rose S, Tomlanovich S, Wilkinson A . Prednisone withdrawal in kidney transplant recipients on cyclosporine and mycophenolate mofetil--a prospective randomized study. Steroid Withdrawal Study Group. Transplantation. 2000; 68(12):1865-74. DOI: 10.1097/00007890-199912270-00009. View

10.

de Mattos A, Olyaei A, Bennett W . Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. Am J Kidney Dis. 2000; 35(2):333-46. DOI: 10.1016/s0272-6386(00)70348-9. View

11.

Whelchel J, Hymes L, Hochgelerent E, Larsen C, Lowance D, OBrien D . Evolving strategies in immunosuppressive therapy: the Emory experience. Clin Transpl. 1996; :249-55. View

12.

Varma P, Prasher P, Madan H, Yashpal B . AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS. Med J Armed Forces India. 2017; 52(1):45-47. PMC: 5530283. DOI: 10.1016/S0377-1237(17)30834-1. View

13.

Jindal R . Posttransplant diabetes mellitus--a review. Transplantation. 1994; 58(12):1289-98. View